| Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction. | |
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MedLine Citation:
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PMID: 10233772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic sun exposure results in photoaged skin with deep coarse wrinkles and loss of elasticity. We have examined the distribution and abundance of fibrillin-rich microfibrils, key structural components of the elastic fiber network, in photoaged and photoprotected skin. Punch biopsies taken from photoaged forearm and from photoprotected hip and upper inner arm of 16 subjects with a clinical range of photoaging were examined for fibrillin-1 and fibrillin-2 expression and microfibril distribution. In situ hybridization revealed decreased fibrillin-1 mRNA but unchanged fibrillin-2 mRNA levels in severely photoaged forearm biopsies relative to photoprotected dermal sites. An immunohistochemical approach demonstrated that microfibrils at the dermal-epidermal junction were significantly reduced in moderate to severely photoaged forearm skin. Confocal microscopy revealed that the papillary dermal microfibrillar network was truncated and depleted in photoaged skin. These studies highlight that the fibrillin-rich microfibrillar network associated with the upper dermis undergoes extensive remodeling following solar irradiation. These changes may contribute to the clinical features of photoaging, such as wrinkle formation and loss of elasticity. |
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Authors:
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R E Watson; C E Griffiths; N M Craven; C A Shuttleworth; C M Kielty |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 112 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-06-18 Completed Date: 1999-06-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 782-7 Citation Subset: IM |
Affiliation:
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School of Biological Sciences, University of Manchester, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Dermis / metabolism*, pathology Epidermis / metabolism*, pathology Extracellular Matrix Proteins / metabolism Female Humans Immunohistochemistry In Situ Hybridization Male Microfilament Proteins / genetics, metabolism* Microscopy, Confocal Middle Aged RNA, Messenger / metabolism Skin Aging / pathology* Sunlight / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Extracellular Matrix Proteins; 0/Microfilament Proteins; 0/RNA, Messenger; 0/fibrillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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