Document Detail

Fibrillation potential onset in peripheral nerve injury.
MedLine Citation:
PMID:  22907222     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Fibrillation potentials are an accepted electrical marker of muscle denervation that occur in axonal nerve injury. Clinically, they are used to determine the type of, and prognosis for nerve injuries. The time of occurrence after nerve injury plays a critical role in clinical decision making. This study explores the evolution of the generally accepted guideline that fibrillation potentials occur 1 to 4 weeks after axonal nerve injury. Methods: Pubmed, Ovid, and EMBASE, and current textbooks were reviewed. References were recursively followed back to the initial description of fibrillation potentials. Results: The majority of our understanding regarding the timing of onset of fibrillation potentials appears to arise from animal experiments in the mid-20th century. Conclusions: Despite frequent use in human clinical care, published evidence for the 1 to 4 week guideline comes almost entirely from animal studies. An appreciation of this background and resulting limitations aids clinical application of this guideline. Muscle Nerve 46: 332-340, 2012.
Andrew D Willmott; Chris White; Sean P Dukelow
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  46     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Physical Medicine and Rehabilitation, University of Calgary, Calgary, Alberta, Canada.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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