Document Detail

Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes.
MedLine Citation:
PMID:  9158204     Owner:  NLM     Status:  MEDLINE    
Fibrillary glomerulonephritis is a disease of uncertain origin and pathogenesis characterized by nonamyloidotic fibrils in glomeruli. We report immunohistological, immunochemical, and biochemical studies of a serum fibrillar cryoprecipitate obtained from a patient with fibrillary glomerulonephritis, that formed on prolonged storage at 4 degrees C. By Western blot and amino acid sequence analysis, the cryoprecipitated fibril components consisted of immunoglobulins, heavy chains gamma and mu, light chains kappa and lambda, and fibronectin, similar to the proteins identified by immunofluorescence and immunoelectron microscopy in the glomerular fibrils. These findings support the hypothesis that serum precursors may be the source of the fibrillar deposits and suggest a role for immunoglobulin-fibronectin complexes in the pathogenesis of fibrillary glomerulonephritis.
A Rostagno; R Vidal; A Kumar; J Chuba; G Niederman; L Gold; B Frangione; J Ghiso; G Gallo
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  28     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  676-84     Citation Subset:  IM    
Department of Pathology, New York University Medical Center, New York 10016, USA.
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MeSH Terms
Antigen-Antibody Complex / blood*,  metabolism
Blotting, Western
Cryoglobulins / analysis*,  metabolism
Fibronectins / blood*,  metabolism
Glomerulonephritis / blood,  immunology,  pathology*
Immunoglobulins / blood*,  metabolism
Kidney Glomerulus / chemistry,  pathology*
Microscopy, Electron
Microscopy, Immunoelectron
Middle Aged
Grant Support
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Cryoglobulins; 0/Fibronectins; 0/Immunoglobulins

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