Document Detail

Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes.
MedLine Citation:
PMID:  9158204     Owner:  NLM     Status:  MEDLINE    
Fibrillary glomerulonephritis is a disease of uncertain origin and pathogenesis characterized by nonamyloidotic fibrils in glomeruli. We report immunohistological, immunochemical, and biochemical studies of a serum fibrillar cryoprecipitate obtained from a patient with fibrillary glomerulonephritis, that formed on prolonged storage at 4 degrees C. By Western blot and amino acid sequence analysis, the cryoprecipitated fibril components consisted of immunoglobulins, heavy chains gamma and mu, light chains kappa and lambda, and fibronectin, similar to the proteins identified by immunofluorescence and immunoelectron microscopy in the glomerular fibrils. These findings support the hypothesis that serum precursors may be the source of the fibrillar deposits and suggest a role for immunoglobulin-fibronectin complexes in the pathogenesis of fibrillary glomerulonephritis.
A Rostagno; R Vidal; A Kumar; J Chuba; G Niederman; L Gold; B Frangione; J Ghiso; G Gallo
Related Documents :
18780974 - Differential changes in synaptic proteins in the alzheimer frontal cortex with marked i...
8858934 - Phorbol esters but not the cholinergic agonists oxotremorine-m and carbachol increase r...
16981674 - Hydrogen/deuterium exchange mass spectrometry--a window into amyloid structure.
9202294 - Isoform-specific modulation by apolipoprotein e of the activities of secreted beta-amyl...
19098104 - Functional comparison of rgs9 splice isoforms in a living cell.
9695844 - A new beat for the snare drum.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  28     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  676-84     Citation Subset:  IM    
Department of Pathology, New York University Medical Center, New York 10016, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigen-Antibody Complex / blood*,  metabolism
Blotting, Western
Cryoglobulins / analysis*,  metabolism
Fibronectins / blood*,  metabolism
Glomerulonephritis / blood,  immunology,  pathology*
Immunoglobulins / blood*,  metabolism
Kidney Glomerulus / chemistry,  pathology*
Microscopy, Electron
Microscopy, Immunoelectron
Middle Aged
Grant Support
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Cryoglobulins; 0/Fibronectins; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Familial glomerulopathy with giant fibrillar (fibronectin-positive) deposits: 15-year follow-up in a...
Next Document:  Intercellular adhesion molecule-1, intercellular adhesion molecule-3, and leukocyte integrins in leu...