| Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes. | |
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MedLine Citation:
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PMID: 9158204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrillary glomerulonephritis is a disease of uncertain origin and pathogenesis characterized by nonamyloidotic fibrils in glomeruli. We report immunohistological, immunochemical, and biochemical studies of a serum fibrillar cryoprecipitate obtained from a patient with fibrillary glomerulonephritis, that formed on prolonged storage at 4 degrees C. By Western blot and amino acid sequence analysis, the cryoprecipitated fibril components consisted of immunoglobulins, heavy chains gamma and mu, light chains kappa and lambda, and fibronectin, similar to the proteins identified by immunofluorescence and immunoelectron microscopy in the glomerular fibrils. These findings support the hypothesis that serum precursors may be the source of the fibrillar deposits and suggest a role for immunoglobulin-fibronectin complexes in the pathogenesis of fibrillary glomerulonephritis. |
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Authors:
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A Rostagno; R Vidal; A Kumar; J Chuba; G Niederman; L Gold; B Frangione; J Ghiso; G Gallo |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 28 ISSN: 0272-6386 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-06-09 Completed Date: 1997-06-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 676-84 Citation Subset: IM |
Affiliation:
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Department of Pathology, New York University Medical Center, New York 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigen-Antibody Complex
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blood*,
metabolism Blotting, Western Cryoglobulins / analysis*, metabolism Female Fibronectins / blood*, metabolism Glomerulonephritis / blood, immunology, pathology* Humans Immunoglobulins / blood*, metabolism Kidney Glomerulus / chemistry, pathology* Microscopy, Electron Microscopy, Immunoelectron Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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AI 32110/AI/NIAID NIH HHS; AR 02594/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Cryoglobulins; 0/Fibronectins; 0/Immunoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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