| Fibrillar and oligomeric beta-amyloid as distinct local biomarkers for Alzheimer's disease. | |
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MedLine Citation:
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PMID: 17413026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beta-amyloid is a key component of Alzheimer's disease (AD) pathology. Researchers in both academic and industry are actively pursuing the development of imaging tracers and techniques to noninvasively measure local levels of beta-amyloid in the Alzheimer's brain. This presentation summarizes recent data and discusses the opportunities and challenges of imaging plaques containing fibrillar beta-amyloid for the early diagnosis and therapeutic monitoring of amyloid targeted therapies. Further, the value and feasibility of measuring the recently described soluble oligomeric form of beta-amyloid as an alternative noninvasive biomarker is also discussed. |
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Authors:
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Michael C Montalto; Gill Farrar; Cristina Tan Hehir |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1097 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-04-06 Completed Date: 2007-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 239-58 Citation Subset: IM |
Affiliation:
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Molecular Imaging and Diagnostics Advanced Technology Program, Biosciences, GE Global Research Center, Niskayuna, New York, USA. montalto@crd.ge.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism*,
pathology* Amyloid beta-Protein / metabolism*, ultrastructure* Biological Markers Blood-Brain Barrier / physiology Brain / pathology Brain Chemistry / physiology Humans Senile Plaques / metabolism*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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