Document Detail


Fibrates and estimated glomerular filtration rate: observations from an outpatient clinic setting and clinical implications.
MedLine Citation:
PMID:  22460858     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundPrevious studies have demonstrated that fibrates have an effect on creatinine concentrations. The pattern of change with fibrates in estimated glomerular filtration rate (eGFR), widely used in clinical practice, has not been previously described.MethodsData was retrospectively collected from 132 consecutive case notes of patients started on fibrates in a lipid clinic between 2002 and 2008. Pre- and post-fibrate creatinine concentrations were measured and eGFR measurements were obtained.ResultsOf the 79 patients with both pre and post-treatment eGFR values <90 ml/min/1.73 m(2), a significant mean eGFR reduction of 8.2 ml/min/1.73 m(2) was noted. Of these patients, 50% demonstrated a reduction in eGFR >8 ml/min/1.73 m(2), 25% demonstrated a reduction >16 ml/min/1.73 m(2), and 10% demonstrated a reduction >21 ml/min/1.73 m(2).ConclusionsThe authors demonstrate a significant effect of fibrates on eGFR in clinical practice. Awareness of the pattern of eGFR change is important for decisions regarding the continued use of fibrate therapy and/or commonly co-prescribed diabetic drugs and renal specialist referrals.
Authors:
Ahmed Abbas; Sanjay Saraf; Shanath Ramachandran; Jessie Raju; Sudarshan Ramachandran
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-29
Journal Detail:
Title:  Postgraduate medical journal     Volume:  -     ISSN:  1469-0756     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Good Hope Hospital, Birmingham, UK.
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