Document Detail

Fiber size and myosin phenotypes of selected rhesus lower limb muscles after a 14-day spaceflight.
MedLine Citation:
PMID:  11543457     Owner:  NASA     Status:  MEDLINE    
Muscle biopsies were taken from the rhesus (Macaca mulatta) soleus (Sol, a slow ankle extensor), medial gastrocnemius (MG, a fast ankle extensor), tibialis anterior (TA, a fast ankle flexor), and vastus lateralis (VL, a fast knee extensor) muscles in vivarium controls (n=5) before and after either a 14-day spaceflight (Bion 11, n=2) or a 14-day ground-based flight simulation (n=3). Myosin heavy chain (MHC) composition (gel electrophoresis), fiber type distribution (immunohistochemistry), and fiber size were determined. Although there were no significant changes, each muscle showed trends towards adaptation.
R R Roy; H Zhong; S C Bodine; D J Pierotti; R J Talmadge; G Barkhoudarian; J Kim; J W Fanton; I B Kozlovskaya; V R Edgerton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology     Volume:  7     ISSN:  1077-9248     ISO Abbreviation:  J Gravit Physiol     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-11-11     Completed Date:  2000-11-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9437868     Medline TA:  J Gravit Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S45     Citation Subset:  S    
Brain Research Institute, University of California, Los Angeles, USA.
Space Flight Mission:
Bion 11 Project; Flight Experiment; short duration; unmanned
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MeSH Terms
Macaca mulatta
Muscle Fibers, Fast-Twitch / metabolism,  pathology
Muscle Fibers, Slow-Twitch / metabolism,  pathology
Muscle, Skeletal / metabolism,  pathology*
Muscular Atrophy / etiology*,  metabolism,  pathology
Myosin Heavy Chains / metabolism*
Space Flight*
Weightlessness / adverse effects*
Reg. No./Substance:
0/Myosin Heavy Chains
S C Bodine / VA Med Ctr, San Diego, CA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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