| Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration. | |
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MedLine Citation:
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PMID: 20532963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-alpha-2,8-N-acetylneuraminic acid) a photoactive derivative (poly-alpha-2,8-N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells. |
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Authors:
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Ulrike Assmann; Andreas Szentivanyi; Yvonne Stark; Thomas Scheper; Silke Berski; Gerald Dräger; Robert H Schuster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-09 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 21 ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-07 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 2115-24 Citation Subset: IM |
Affiliation:
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Deutsches Institut für Kautschuktechnologie e.V., Eupener Strasse 33, 30519 Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation Cells, Cultured Guided Tissue Regeneration N-Acetylneuraminic Acid Nerve Regeneration / physiology* Peripheral Nerves* Schwann Cells / physiology Sialic Acids* Tissue Scaffolds* |
| Chemical | |
Reg. No./Substance:
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0/Sialic Acids; 0/polysialic acid; 131-48-6/N-Acetylneuraminic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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