Document Detail


Fiber-reinforced hydrogel scaffolds for heart valve tissue engineering.
MedLine Citation:
PMID:  24733776     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart valve-related disorders are among the major causes of death worldwide. Although prosthetic valves are widely used to treat this pathology, current prosthetic grafts cannot grow with the patient while maintaining normal valve mechanical and hemodynamic properties. Tissue engineering may provide a possible solution to this issue through using biodegradable scaffolds and patients' own cells. Despite their similarity to heart valve tissue, most hydrogel scaffolds are not mechanically suitable for the dynamic stresses of the heart valve microenvironment. In this study, we integrated electrospun poly(glycerol sebacate) (PGS)-poly(ε-caprolactone) (PCL) microfiber scaffolds, which possess enhanced mechanical properties for heart valve engineering, within a hybrid hydrogel made from methacrylated hyaluronic acid and methacrylated gelatin. Sheep mitral valvular interstitial cells were encapsulated in the hydrogel and evaluated in hydrogel-only, PGS-PCL scaffold-only, and composite scaffold conditions. Although the cellular viability and metabolic activity were similar among all scaffold types, the presence of the hydrogel improved the three-dimensional distribution of mitral valvular interstitial cells. As seen by similar values in both the Young's modulus and the ultimate tensile strength between the PGS-PCL scaffolds and the composites, microfibrous scaffolds preserved their mechanical properties in the presence of the hydrogels. Compared to electrospun or hydrogel scaffolds alone, this combined system may provide a more suitable three-dimensional structure for generating scaffolds for heart valve tissue engineering.
Authors:
Maryam Eslami; Nihal Engin Vrana; Pinar Zorlutuna; Shilpa Sant; Sungmi Jung; Nafiseh Masoumi; Ramazan Ali Khavari-Nejad; Gholamreza Javadi; Ali Khademhosseini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-14
Journal Detail:
Title:  Journal of biomaterials applications     Volume:  -     ISSN:  1530-8022     ISO Abbreviation:  J Biomater Appl     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8813912     Medline TA:  J Biomater Appl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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