| Fiber intakes and anthropometric measures are predictors of circulating hormone, triglyceride, and cholesterol concentrations in the women's health trial. | |
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MedLine Citation:
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PMID: 16857849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The unhealthy eating patterns and obesity among women in the U.S. are indicated by changes in biomarkers, such as insulin, lipoproteins, and estradiol, that are risk factors for breast cancer and cardiovascular diseases. This article models the inter-relations among diet, serum insulin, estradiol, and sex hormone binding globulin (SHBG) concentrations, plasma LDL and HDL cholesterol, and net triglyceride concentrations, using the data at baseline and 12 mo on 379 and 615 postmenopausal women in the Control and Intervention groups, respectively, of the Women's Health Trial: Feasibility Study in Minority Populations. Subjects in the Intervention group received detailed advice over a period of 1 y for reducing fat intakes and increasing the consumption of whole grains and fruits and vegetables. The main findings were that there were significant differences between the Control and Intervention groups in the changes from baseline to 12 mo in LDL and HDL cholesterol and SHBG concentrations. Second, using a comprehensive random effects modeling framework, the ratio of fiber to energy intake was significantly associated (P < 0.05) with lower insulin and triglyceride levels, and with a higher HDL cholesterol concentration in the Intervention group. Third, the subjects' waist-to-hip ratio and BMI were significantly associated with insulin, SHBG, LDL and HDL cholesterol, and triglyceride concentrations. Fourth, insulin levels were significantly negatively associated with SHBG and HDL cholesterol, and positively associated with LDL cholesterol, triglyceride, and estradiol concentrations. Overall, weight loss, especially around the waist, and increased fiber intakes are likely to be beneficial for lipid, cholesterol, and hormone profiles of U.S. women. |
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Authors:
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Alok Bhargava |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of nutrition Volume: 136 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-21 Completed Date: 2006-08-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 2249-54 Citation Subset: IM |
Affiliation:
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Department of Economics, University of Houston, Houston, TX 77204-5019, USA. bhargava@uh.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anthropometry* Cholesterol / blood* Dietary Fiber / administration & dosage* Female Humans Insulin / blood Middle Aged Models, Biological Multicenter Studies as Topic Postmenopause Predictive Value of Tests Randomized Controlled Trials as Topic Risk Factors Sex Hormone-Binding Globulin / metabolism* Triglycerides / blood* United States Women's Health* |
| Grant Support | |
ID/Acronym/Agency:
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R03 CA 97738/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sex Hormone-Binding Globulin; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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