Document Detail

Fiber and cancer protection--mechanisms.
MedLine Citation:
PMID:  9361850     Owner:  NLM     Status:  MEDLINE    
There is no reason to believe that a single lumenal or tissue factor will hold the key to understanding the of dietary fiber's effect on reducing the risk of colon cancer. In fact, the data suggest that multiple, interacting factors will be revealed. After years of research, it appears that the bile acid hypothesis is not nearly as strong as first envisaged. Additionally, the theory that SCFA protect against colon cancer has little clinical or experimental support. There is no doubt that identification of genetic alterations, and their controlling factors, will play a major role in our understanding of this issue. The appeal of the original fiber hypothesis has not diminished but simply requires updating based on discoveries made since it was first proposed. It is this author's opinion that dietary fiber will likely be found to modulate human colon cancer and the mechanisms of its beneficial effect will probably be through multiple actions within the lumen and at the level of the target tissue. Based on our current knowledge of the pathogenesis of colon cancer we cannot make definitive statements about what percentage of colon cancer might be prevented by a specific type or amount of dietary fiber but it is reasonable to conclude that consumption of fiber-rich diets is associated with reduced risk of colon cancer. It is quite plausible that the combination of dietary fiber, or its metabolites, in conjunction with other phytochemicals may be necessary to realize inhibition of the tumorigenic process.
D M Klurfeld
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  427     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-12-12     Completed Date:  1997-12-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
Department of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, USA.
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MeSH Terms
Bile Acids and Salts
Cell Division
Dietary Fiber / administration & dosage,  therapeutic use*
Intestines / metabolism,  pathology
Neoplasms / etiology,  genetics,  pathology,  prevention & control*
Reg. No./Substance:
0/Bile Acids and Salts

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