Document Detail

Fiber burden and patterns of asbestos-related disease in workers with heavy mixed amosite and chrysotile exposure.
MedLine Citation:
PMID:  8087335     Owner:  NLM     Status:  MEDLINE    
To attempt to determine the mineralogic factors that relate to the appearance of specific types of asbestos-related disease in workers with heavy mixed exposure to amphiboles and chrysotile, we analyzed the pulmonary asbestos fiber burden in a series of 144 shipyard workers and insulators from the Pacific Northwest. Amosite was found in all lungs, and tremolite and chrysotile in most lungs, but the vast majority of fibers were amosite. Tremolite and chrysotile concentrations were significantly correlated, indicating that the tremolite originated from chrysotile products, but no correlation was found between tremolite or chrysotile concentration and amosite concentration. Time since last exposure was correlated with decreasing amosite concentration and the calculated clearance half time was about 20 yr. In a multiple regression analysis that accounted for the presence of more than one disease in many subjects, a high concentration of amosite fibers was correlated with the presence of airway fibrosis and asbestosis, whereas subjects with mesothelioma, lung cancer, pleural plaques, or no asbestos-related disease had about the same, much lower, amosite concentration. No relationship was found between the concentration of chrysotile or tremolite and any disease. Analysis of fiber size measures (length, width, aspect ratio, surface, mass) showed that pleural plaques were strongly associated with high aspect ratio amosite fibers and suggested that mesotheliomas were associated with low aspect ratio amosite fibers.(ABSTRACT TRUNCATED AT 250 WORDS)
A Churg; S Vedal
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  150     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-10-20     Completed Date:  1994-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  663-9     Citation Subset:  AIM; IM    
Department of Pathology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Aged, 80 and over
Asbestos, Amosite / adverse effects*,  analysis
Asbestos, Amphibole / adverse effects,  analysis
Asbestos, Serpentine / adverse effects*,  analysis
Asbestosis / epidemiology,  etiology,  pathology*
British Columbia / epidemiology
Construction Materials / adverse effects
Lung / chemistry,  ultrastructure
Middle Aged
Northwestern United States / epidemiology
Occupational Exposure / adverse effects*,  statistics & numerical data
Regression Analysis
Time Factors
Reg. No./Substance:
0/Asbestos, Amphibole; 0/Asbestos, Serpentine; 12172-73-5/Asbestos, Amosite; 14567-73-8/tremolite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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