Document Detail

Fever of unknown origin in a Mediterranean survey from a division of internal medicine: report of 91 cases during a 12-year-period (1991-2002).
MedLine Citation:
PMID:  18264668     Owner:  NLM     Status:  MEDLINE    
Despite the availability of all advanced diagnostic tools, fever of unknown origin (FUO) remains a diagnostic challenge for physicians. The objective was to define, through a retrospective study, the categories of the diseases of Sicilian patients admitted at the Department of Clinical Medicine and Emerging Diseases, University of Palermo, Italy, for classical FUO. Using the registration system for patients admitted from 1991 to 2002, 508 charts of patients admitted because of fever were reviewed. Of these, only 91 patients fulfilled the criteria for classical FUO. The origin of FUO was diagnosed in 62 (68.1%) patients. Infection was the most common cause of FUO with 29 cases (31.8% of total of FUO), neoplasms accounted for 13 cases (14.2%), collagen vascular disease for 11 cases (12.0%), and miscellaneous for 9 cases (9.8%). Undiagnosed FUO were 29 (31.8%) and, of them, 22 cases were followed-up for 2 years. A definite diagnosis could be established only in 8 cases, 13 subjects completely recovered and 4 of them died. In the 73.4% of cases, the FUO have been the result of misleading factors in the diagnostic approaches as made by the physician. The results of our study are similar to those already reported by other authors in other populations, with infections as first, neoplasm as second, and collagen vascular diseases as third most important causes of FUO. In our study the prognosis for undiagnosed FUO cases was good, but a definite diagnosis could be established only in few cases. Therefore, further multicentric, prospective studies of good design are required.
Pasquale Mansueto; Gabriele Di Lorenzo; Manfredi Rizzo; Salvatore Di Rosa; Giustina Vitale; GiovamBattista Rini; Serafino Mansueto; Mario Affronti
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Publication Detail:
Type:  Journal Article     Date:  2008-02-09
Journal Detail:
Title:  Internal and emergency medicine     Volume:  3     ISSN:  1828-0447     ISO Abbreviation:  -     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101263418     Medline TA:  Intern Emerg Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
Dipartimento di Medicina Clinica e delle Patologie Emergenti, Università di Palermo, Via del Vespro, 141, 90127, Palermo, Italy.
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MeSH Terms
Fever of Unknown Origin / epidemiology*,  etiology
Italy / epidemiology
Middle Aged
Retrospective Studies

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