Document Detail

Fever management: evaluating the use of ibuprofen and paracetamol.
MedLine Citation:
PMID:  20426354     Owner:  NLM     Status:  MEDLINE    
Paracetamol and ibuprofen are safe and effective medications for reducing a fever in children and young people and they are often administered together with a view to reducing a temperature quickly. National Institute for Health and Clinical Excellence guidelines dictate that only one of these drugs should be given at a time because there is no evidence to suggest that simultaneous use is more effective. This article summarises a literature search of randomised controlled trials carried out to identify which, if either, of these drugs is faster at reducing a fever. In the studies examined, ibuprofen was found to be marginally more effective. However, the maximum dose of paracetamol was not administered. There is a need for more methodologically sound research that uses equivalent doses of both drugs.
Jodie Crook
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Paediatric nursing     Volume:  22     ISSN:  0962-9513     ISO Abbreviation:  Paediatr Nurs     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013329     Medline TA:  Paediatr Nurs     Country:  England    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  N    
A & E Department, Ealing Hospital NHS Trust, London.
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MeSH Terms
Acetaminophen / adverse effects,  therapeutic use*
Analgesics, Non-Narcotic / adverse effects,  therapeutic use*
Drug Administration Schedule
Emergency Nursing
Fever / drug therapy*
Ibuprofen / adverse effects,  therapeutic use*
Patient Selection*
Pediatric Nursing
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Research Design
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen; 15687-27-1/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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