| Fever and intracranial pressures. | |
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MedLine Citation:
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PMID: 4052827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of fever upon intracranial pressures was determined in the rabbit and cat. In the unanesthetized rabbit and cat, cerebrospinal fluid (CSF) pressure was measured via direct cannulation of the lateral cerebral ventricle. Intracranial pressure (ICP) was measured in the rabbit by a subarachnoid screw technique. In all cases, intravenous administration of bacterial pyrogen extracted from Salmonella abortus equi resulted in significant differences from controls in physiological variables measured during the initial "chill" phase of the fever. There was an increase in body temperature, a fall in CSF or ICP pulse rate, an increase in pulse pressure amplitude, and a small increase in mean CSF or ICP. In addition, venous and arterial blood pressures increased significantly and, consistent with heat conservation, there was a fall in respiratory rate as well as cutaneous vasoconstriction in the ears. The arterial carbon dioxide tension was unchanged during the prodrome but fell significantly during the chill and flush phases and rose again during defervescence. The results suggest that in these animals there is a slight increase in pressures within the cranium during the "chill" phase of a pyrogen induced fever, resulting from changes occurring in many body systems during this phase of the fever. |
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Authors:
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T J Malkinson; W L Veale; K E Cooper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research bulletin Volume: 15 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-12-13 Completed Date: 1985-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 315-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Fever / etiology, physiopathology* Heart Rate / drug effects Intracranial Pressure* Pyrogens / administration & dosage Rabbits Respiration / drug effects Salmonella / analysis Salmonella Infections, Animal / physiopathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Pyrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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