Document Detail

Fever in uremia: production of leukocytic pyrogen by chronic dialysis patients.
MedLine Citation:
PMID:  3876765     Owner:  NLM     Status:  MEDLINE    
Uremic patients frequently have low baseline temperatures and a blunted febrile response to infection. We investigated the first step in the generation of a febrile response, the production of leukocytic pyrogen (LP) by blood monocytes, in 12 patients on chronic hemodialysis, five patients on continuous ambulatory peritoneal dialysis (CAPD), and 17 control subjects. No significant differences were found in the amount of LP produced by hemodialysis patients, CAPD patients, and control subjects. Uremic serum did not decrease LP production by monocytes from control subjects. Hemodialysis patients who were consistently hypothermic (mean oral predialysis temperature less than or equal to 35.6 degrees F) produced as much LP as those with more normal oral temperatures (mean oral predialysis temperature greater than or equal to 36.8 degrees F). Decreased production of LP does not explain the blunted febrile response noted in patients with chronic renal failure.
P G Jones; C A Kauffman; F K Port; M J Kluger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  6     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-08     Completed Date:  1985-11-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
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MeSH Terms
Bacterial Infections / physiopathology
Blood Cell Count
Blood Urea Nitrogen
Body Temperature Regulation
Hypothermia / etiology*
Interleukin-1 / analysis
Kidney Failure, Chronic / physiopathology,  therapy*
Middle Aged
Peritoneal Dialysis*
Peritoneal Dialysis, Continuous Ambulatory*
Protein Biosynthesis*
Renal Dialysis*
Grant Support
Reg. No./Substance:
0/Interleukin-1; 0/leukocyte endogenous mediator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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