| Fever and feeding in the rat: actions of intrahypothalamic interleukin-6 compared to macrophage inflammatory protein-1 beta (MIP-1 beta). | |
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MedLine Citation:
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PMID: 7807590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/POA), a region containing thermosensitive neurons. The purpose of this study was to compare the central action on body temperature (Tb) of MIP-1 beta with that of interleukin-6 (IL-6), which also has been implicated in the cerebral mechanism underlying the pathogenesis of fever. Following the stereotaxic implantation in the AH/POA of guide cannulae for repeated micro-injections, radio transmitters which monitor Tb continuously were inserted intraperitoneally in each of 15 male Sprague-Dawley rats. Each micro-injection was made in a site in the AH/POA in a volume of 1.0 microliter of pyrogen-free artificial CSF, recombinant murine MIP-1 beta, or recombinant human IL-6. MIP-1 beta in a dose of 25 pg evoked an intense fever characterized by a short latency, a mean maximum rise in Tb of 2.4 +/- 0.21 degrees C reached by 3.7 +/- 0.42 hr, and a duration exceeding 6.5 hr. Injected into homologous sites in the AH/POA, IL-6 induced a dose dependent fever of similar latency and a mean maximal increase in Tb of 1.2 +/- 0.25 degrees C, 1.8 +/- 0.15 degrees C, and 2.1 +/- 0.22 degrees C and duration of 6.2 +/- 1.28 hr, 6.7 +/- 0.49 hr, and 6.8 +/- 0.65 hr when given in doses of 25, 50, and 100 ng, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R D Myers; F J Lopez-Valpuesta; F J Miñano; M H Wooten; V S Barwick; S D Wolpe |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of neuroscience research Volume: 39 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-01-30 Completed Date: 1995-01-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Medicine, East Carolina University, Greenville, North Carolina 27858-4354. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anorexia / chemically induced*, physiopathology Appetite / physiology Body Temperature Regulation / drug effects Chemokine CCL4 Cytokines / administration & dosage, toxicity* Dose-Response Relationship, Drug Fever / chemically induced*, physiopathology Humans Interleukin-6 / administration & dosage, toxicity* Macrophage Inflammatory Proteins Male Microinjections Monokines / administration & dosage, toxicity* Preoptic Area / drug effects*, physiopathology Rats Rats, Sprague-Dawley Recombinant Proteins / toxicity Stereotaxic Techniques |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL4; 0/Cytokines; 0/Interleukin-6; 0/Macrophage Inflammatory Proteins; 0/Monokines; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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