Document Detail

Fetuses with obstructive uropathies complicated by urinary ascites: outcome and prognostic value of fetal serum beta-2-microglobulin.
MedLine Citation:
PMID:  23090907     Owner:  NLM     Status:  Publisher    
Objective: To demonstrate that in the case of fetal urinary ascites 1) the prognostic value of fetal serum β2-microglobulin in obstructive uropathies is not modified, 2) occurrence of fetal urinary ascites does not prevent kidney damage. Methods: We conducted a retrospective study, between 2006 and 2010. Cases of fetal bilateral obstructive uropathy for which both fetal serum and ascites were sampled were analyzed in our laboratory. β2-microglobulin was assayed in both fetal serum and the corresponding ascites. Renal outcome was analyzed. Histological features of the kidney in cases of termination of pregnancy and renal function of live-born infants were recorded. Results: 14 cases of fetal blood and fetal ascites in a context of urinary obstruction were included. Renal outcome was unfavorable in 8/14 cases (57%) and favorable in 6. When fetal serum β2-microglobulin was < 5 mg/L, renal outcome was favorable in all cases (4/4). When fetal serum β2-microglobulin was ≥ 5 mg/L, 8/10 cases (80%) had an unfavorable renal outcome (sensitivity 100% and specificity 66%). Conclusion: Fetal serum β2-microglobulin reliably predicts postnatal renal outcome in obstructive uropathies complicated by urinary ascites. Moreover, urine extravasation does not seem to protect fetal renal function. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Emmanuel Spaggiari; Sophie Dreux; Isabelle Czerkiewicz; Romain Favre; Thomas Schmitz; Fabien Guimiot; Hélène Laurichesse Delmas; Eric Verspyck; Jean-François Oury; Yves Ville; Françoise Muller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-22
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Developmental Biology, AP-HP, Robert Debré Hospital, and University Paris Diderot and Paris Sorbonne-Cité, Paris, France.
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