| Fetuses subsequently born premature are smaller than gestational age-matched fetuses not born premature. | |
MedLine Citation:
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PMID: 12693619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether singleton fetuses in pregnancies that subsequently deliver prematurely are smaller than singleton fetuses of the same gestational age who are not born premature. METHODS: Our study population consisted of singleton pregnancies meeting the following criteria: at least 1 first-trimester sonogram (to ensure accurate dating), at least 1 sonogram after 24 weeks' gestation, and a known delivery date. Controlling for gestational age at sonography using analysis of covariance, we compared very premature fetuses (delivery at 24-29.9 weeks; n = 26) and moderately premature fetuses (delivery at 30-36.9 weeks; n = 306) with nonpremature fetuses (n = 1,838) with respect to the following sonographic parameters: abdominal diameter, femur length, biparietal diameter, and estimated fetal weight. RESULTS: On 24- to 29.9-week sonograms, fetuses who were subsequently born very premature had significantly smaller fetal measurements than did fetuses who were not born premature (P < .05 for all parameters). Even after excluding 9 very premature fetuses with a risk factor for uteroplacental insufficiency (e.g., toxemia or hypertension), the remaining 17 fetuses had significantly smaller abdominal diameters, femur lengths, and estimated fetal weights than nonpremature fetuses (P < .05). Sonographic parameters in moderately premature fetuses were smaller than in nonpremature fetuses on 30- to 36.9-week sonograms (P < .05 for all parameters), but the only parameters that differed significantly between these 2 groups on 24- to 29.9-week sonograms were abdominal diameter and femur length. CONCLUSIONS. Singleton fetuses subsequently born premature are smaller than gestational age-matched fetuses not born premature, even in the absence of an identifiable cause of growth restriction. The lag in growth appears to occur in the last few weeks before delivery. |
Authors:
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Peter M Doubilet; Carol B Benson; Louise Wilkins-Haug; Steven Ringer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 22 ISSN: 0278-4297 ISO Abbreviation: J Ultrasound Med Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-15 Completed Date: 2003-07-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: United States |
Other Details:
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Languages: eng Pagination: 359-63 Citation Subset: IM |
Affiliation:
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Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight* Female Gestational Age* Humans Infant, Newborn Infant, Premature / physiology* Pregnancy Pregnancy Trimester, Third Ultrasonography, Prenatal |
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