| Fetuin-A, coronary artery calcification and outcome in maintenance hemodialysis patients. | |
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MedLine Citation:
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PMID: 21543017 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background/Aims: Previous studies have suggested that serum fetuin-A, a calcification inhibitor, predicts mortality in dialysis patients. This study investigated the relationships between fetuin-A, vascular calcification, and outcome in such patients. Methods: 58 patients on maintenance hemodialysis underwent multirow spiral computed tomography to determine baseline coronary artery calcification (CAC) score. Serum fetuin-A was measured repeatedly over time. Results: Time-averaged fetuin-A inversely correlated with age and baseline CAC score. After partial correlation analysis controlling for age, the association between fetuin-A and CAC became insignificant. During the study, 27 of 58 patients died and 26 experienced at least one cardiovascular event. Low fetuin-A was associated with a significant increase in all-cause mortality and the occurrence of a cardiovascular event. The association of fetuin-A with mortality and cardiovascular event remained significant even when adjusting for confounding factors, including age and CAC score. Conclusion: Time-averaged fetuin-A was associated with survival and cardiovascular outcome, independent of vascular calcification. |
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Authors:
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H H Jung; H J Baek; S-W Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 75 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 391-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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