Document Detail


Fetuin A concentration in the second trimester amniotic fluid of fetuses with trisomy 21 appears to be lower: phenotypic considerations.
MedLine Citation:
PMID:  22489108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We investigated whether the concentration of the glycoprotein fetuin A is altered in the second trimester amniotic fluid of trisomy 21 pregnancies compared with euploid pregnancies.
METHODS: 25 pregnancies with an extra chromosome 21 were matched for maternal and gestational age with 25 pregnancies with normal karyotype. Levels of fetuin A in amniotic fluid were measured by a commercially available enzyme-linked immunosorbent assay (ELISA) kit.
RESULTS: The median concentration of fetuin A in amniotic fluid of trisomy 21 pregnancies (5.3 ng/ml) was statistically significantly lower (P value = 0.008) compared with that in euploid pregnancies (6.8 ng/mL).
CONCLUSION: Lower levels of fetuin A in trisomy 21 may indicate an association with altered metabolic pathways in this early stage that could potentially be associated with features of the syndrome, such as growth restriction or impaired osteogenesis.
Authors:
S Iliodromiti; N Vrachnis; Evangelia Samoli; Z Iliodromiti; C Pangalos; N Drakoulis; G Creatsas; D Botsis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-06
Journal Detail:
Title:  Mediators of inflammation     Volume:  2012     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-10     Completed Date:  2012-07-02     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  138971     Citation Subset:  IM    
Affiliation:
2nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieion Hospital, 124B Vas. Sofias Avenue, 115 26 Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid / metabolism*
Chromosomes, Human, Pair 21 / genetics
Down Syndrome / genetics*
Enzyme-Linked Immunosorbent Assay
Female
Fetus / metabolism*
Humans
Pregnancy
Pregnancy Trimester, Second / metabolism*
alpha-2-HS-Glycoprotein / metabolism*
Chemical
Reg. No./Substance:
0/alpha-2-HS-Glycoprotein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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