| Fetuin-A is associated with calcified coronary artery disease. | |
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MedLine Citation:
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PMID: 20436350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in cardiovascular disease is still controversial. As diabetes and uremia make the role of fetuin-A in cardiovascular disease uncertain, we investigated the association between fetuin-A and calcified coronary artery disease in participants without diabetes and renal dysfunction. METHODS: Serum fetuin-A levels were measured in 92 participants who underwent coronary angiography. The number of diseased vessels and the presence of calcification were evaluated. RESULTS: Fetuin-A levels significantly decreased in patients with advanced three-vessel disease compared with those without stenosis (245.5+/-50.9, 289.0+/-71.8 microg/ml, respectively; P<0.05). Likewise, fetuin-A levels were significantly lower in patients with coronary artery calcification compared with those without coronary artery calcification (257.1+/-49.7, 288.0+/-63.1 microg/ml, respectively; P = 0.010). Multivariate logistic regression analysis revealed that fetuin-A levels inversely correlated with the presence of coronary artery calcification (odds ratio: 0.54; 95% confidence interval: 0.31-0.92; P = 0.025). CONCLUSION: Serum fetuin-A levels inversely correlated with advanced calcified coronary artery disease. |
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Authors:
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Katsuhito Mori; Yuji Ikari; Shuichi Jono; Masanori Emoto; Atsushi Shioi; Hidenori Koyama; Tetsuo Shoji; Eiji Ishimura; Masaaki Inaba; Kazuhiro Hara; Yoshiki Nishizawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Coronary artery disease Volume: 21 ISSN: 1473-5830 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-07 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
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Languages: eng Pagination: 281-5 Citation Subset: IM |
Affiliation:
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Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan. ktmori@med.osaka-cu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Blood Proteins / analysis* Calcinosis / blood*, radiography Chi-Square Distribution Coronary Angiography Coronary Artery Disease / blood*, radiography Disease Progression Down-Regulation Female Humans Logistic Models Male Middle Aged Odds Ratio Prognosis Risk Assessment Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins; 0/alpha2HS glycoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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