| Fetuin-a does not explain ethnic disparity in cardiometabolic risk factors and subclinical atherosclerosis between hispanics and non-Hispanic whites. | |
| | |
MedLine Citation:
|
PMID: 20946008 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract Background: Fetuin-A has been associated with insulin resistance and inversely related with vascular calcification. The present study evaluated whether serum fetuin-A explains the ethnic disparity in the subclinical atherosclerosis and risk for diabetes between healthy Hispanic and non-Hispanic white (NHW) subjects. Methods: Fetuin-A was measured in serum of 76 age-matched healthy males (41 NHW, 35 Hispanics). Bodymass index, blood pressure, serum lipoprotein cholesterol and triglyceride levels, coronary artery calcium (CAC), fasting glucose and insulin concentrations, and plasma glucose levels 2 h after a 75-g oral glucose tolerance test were measured in all participants. Insulin resistance was estimated using the homeostasis model assessment (HOMA). Results: Fasting insulin, fasting and 2-h serum glucose, and HOMA values were all significantly higher in Hispanics (p < 0.05 for all), yet CAC trended lower and the prevalence of very high CAC (>400 Agatston score) was lower (P = 0.03). There was no statistically significant difference in serum fetuin-A when comparing Hispanics and NHW (P = 0.12). Furthermore, there was no correlation between fetuin-A levels and CAC (P = 0.9). Conclusions: Serum fetuin-A concentration was not associated with measures of insulin resistance or with preclinical atherosclerosis in Hispanics and NHW. These data indicate that the disparity in prevalence of insulin resistance, type 2 diabetes, and subclinical atherosclerosis between Hispanics and NHW does not appear attributable to differences in fetuin-A concentrations. |
| | |
Authors:
|
Iyad Syoufi; Juraj Koska; Matthew J Budoff; Peter D Reaven |
Related Documents
:
|
8422788 - Diabetes in st. regis mohawk indians. 8261758 - Metabolic and clinical characteristics of south asians and europeans in coventry. 8462388 - Insulinemia in children at low and high risk of niddm. 20638348 - Prevalence of distal diabetic polyneuropathy using quantitative sensory methods in a po... 8799698 - Epidemiology of late diabetic complications. a basis for the development and evaluation... 7587908 - Effects of insulin therapy upon plasma lipid fatty acids and platelet aggregation in ni... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-14 |
Journal Detail:
|
Title: Metabolic syndrome and related disorders Volume: 9 ISSN: 1557-8518 ISO Abbreviation: Metab Syndr Relat Disord Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101150318 Medline TA: Metab Syndr Relat Disord Country: United States |
Other Details:
|
Languages: eng Pagination: 77-9 Citation Subset: IM |
Affiliation:
|
1 Department of Endocrinology, Phoenix VA Health Care System, Phoenix, Arizona. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between plasma leptin levels and diabetes mellitus.
Next Document: Assessing the impact of health conditions using the ICF.