| Fetotoxic effect of 2,4-dichlorophenoxyacetic acid (2,4-D) in rats. | |
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MedLine Citation:
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PMID: 9972067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fetotoxic effect of 2,4-dichlorophenoxyacetic acid (2,4-D) was investigated. Histological and histochemical changes in the liver of newborn, jung and adult rats exposed to the herbicide from the prenatal period to the end of an experiment were evaluated. The experiment used 90 male and female, Wistar, aged to 10 weeks rats, divided into two groups: I-control-30 and II-60 animals which received the water solution of 2,4-D acid sodium salt in a daily dose of 250 mg/kg b.w. It was given with drinking water every day. The animals were sacrificed after 24 hours, 4, 6, and 10 weeks of the experiment. The results obtained showed that the administration of 2,4-D acid to rats in the prenatal and postnatal period, in a dose inducing subacute intoxication leads to histological and histochemical changes in the liver. The observed changes indicate disorders in energetic processes in hepatocytes and are morphological exponents of detoxicative processes there. They are most intensified with newborn rats. It suggest also, the pregnants ought not to work with 2,4-D and should avoid any contact with herbicides belongs to the 2,4-dichlorophenoxyacetic acid group. |
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Authors:
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M Sulik; B Piłat-Marcinkiewicz; A Sulik; M Barwijuk-Machała; M Sulkowska; M Baltaziak; J Klepacka |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Roczniki Akademii Medycznej w Białymstoku (1995) Volume: 43 ISSN: - ISO Abbreviation: Rocz. Akad. Med. Bialymst. Publication Date: 1998 |
Date Detail:
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Created Date: 1999-03-05 Completed Date: 1999-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9515551 Medline TA: Rocz Akad Med Bialymst Country: POLAND |
Other Details:
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Languages: eng Pagination: 298-308 Citation Subset: IM |
Affiliation:
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Department of Pathological Anatomy, Medical Academy of Białystok. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2,4-Dichlorophenoxyacetic Acid
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administration & dosage,
toxicity* Animals Disease Models, Animal Female Fetus / drug effects* Herbicides / administration & dosage, toxicity* Immunohistochemistry Liver / drug effects*, pathology* Male Pregnancy Pregnancy, Animal / drug effects* Rats Rats, Wistar Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Herbicides; 94-75-7/2,4-Dichlorophenoxyacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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