Document Detail


Fetoplacental vascular alterations associated with fetal growth restriction.
MedLine Citation:
PMID:  25145956     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Placental functional impairment in pregnancies with fetal growth restriction (FGR) can arise from fetoplacental vascular abnormalities. We aimed to compare the micro and macrovasculature of placentas from normal pregnancies with those showing late onset FGR.
METHODS: Placental arterial casts (n = 12 normal, 6 FGR) were prepared. Chorionic arterial number and inter-branch length were examined. Microvascular features were quantified in CD34-stained tissue sections obtained by systematic (n = 12 normal, 12 FGR) and targeted (n = 6 normal, 6 FGR) sampling from the placental periphery and centre.
RESULTS: Adjusted for the weight of the placenta or the surface area of the chorionic plate, the number of chorionic arteries was similar in normal and FGR arterial casts. Inter-branch length per unit placental weight was greater in the first generation of arterial branches in FGR (p < 0.05). Villi in FGR placentas were more poorly vascularised, particularly at the periphery and in grossly visible hypovascular regions. Intermediate and terminal FGR villi in these areas exhibited reduced vessel lumens, loss of CD34, and infilling with CD34-negative cells of what appeared to be previously existing vascular spaces.
CONCLUSION: Differences in chorionic arterial branching patterns between normal and FGR placentas arise from differences in placental size. FGR placentas show microvascular regression and extreme hypovascularity in peripheral areas. These features may well limit the ability of the placenta to meet fetal nutrient requirements late in gestation. Targeted sampling is more effective than systematic random sampling in revealing vascular defects.
Authors:
T O Junaid; P Brownbill; N Chalmers; E D Johnstone; J D Aplin
Related Documents :
12753566 - Prenatal underdevelopment and schizophrenia: a case report of monozygotic twins.
25290496 - Local impact of 'antenatal screening for down syndrome and other conditions' on diagnos...
25200826 - Study of the frequency of occurrence of genetic and acquired thrombophilia in infertile...
25204976 - Exercise before and during pregnancy prevents the deleterious effects of maternal high-...
9127156 - Elevated second trimester human chorionic gonadotropin level associated with adverse pr...
24331836 - Pregnancies of unknown location after in vitro fertilization: minimally invasive manage...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-6
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Switching neuronal state: optimal stimuli revealed using a stochastically-seeded gradient algorithm.
Next Document:  Reduced CD200 and CD200R1 expression in human chorionic villi contributes to early spontaneous abort...