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Fetopathological aspects of holoprosencephaly.
MedLine Citation:
PMID:  22359981     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
MATERIAL AND METHODS: The study included 15 fetuses diagnosed with holoprosencephaly out of 2095 cases analysed post-mortem in the Fetopathology Clinic at the Centre for Maternity and Neonatology in the town of Tunisia over a period of 3 years (Oct. 2006 - Oct. 2009). The fetuses were analysed macro- and microscopically.
RESULTS: All forms of holoprosencephaly include elements of facial dysmorphism with the facial phenotypes of cyclopia, cebocephaly and ethmocephaly. It can be associated with specific internal organs anomalies, the hydrocephaly being the most common anomaly of the central nervous system. Our study suggested that holoprosencephaly can be correlated with craniofacial anomalies affecting the midfacial and medium craniovisceral structures.
CONCLUSION: The anatomical variations of HPE and the phenotypic facial correlations require a systematic and targeted study of central nervous system.
Authors:
Tanya T Kitova; Masmoudi Aida; Zghall Dorra; Chelli Dalenda; Soumeya Siala Gaigi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia medica     Volume:  53     ISSN:  0204-8043     ISO Abbreviation:  Folia Med (Plovdiv)     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2012-02-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984761R     Medline TA:  Folia Med (Plovdiv)     Country:  Bulgaria    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Histology and Embryology, Medical University, Plovdiv, Bulgaria. tanyakitova@yahoo.com
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