Document Detail

Fetomaternal hemorrhage: incidence, risk factors, time of occurrence, and clinical effects.
MedLine Citation:
PMID:  2190367     Owner:  NLM     Status:  MEDLINE    
Most women have only very small amounts of fetal blood in their circulations following pregnancy and delivery: the volume is less than 0.5 mL of whole blood in 93 percent of women, less than 1 mL in 96 percent, and less than 2 mL in 98 percent. FMH of 30 mL or more occurs in just 3 of 1000 women. When the FMH was 150 mL or more, 15 of 41 infants did not survive Rh-negative women with FMH of more than 30 mL of Rh-positive whole blood are at increased risk of Rh immunization, and thus the outcome of their future pregnancies also may be affected. ABO-compatible fetal red cells that have entered the maternal circulation have a life span similar to that of adult cells. ABO-incompatible fetal red cells may be cleared rapidly, but in some cases they circulate for weeks. Most FMHs of 30 mL or more occur before labor, delivery, or cesarean section. The majority occur with minimal clinical signs and symptoms in apparently normal pregnancies. The identification of postpartum Rh-negative women who have 30 mL or more of Rh-positive fetal blood in their circulation is important so that sufficient RhIG for immune suppression can be administered. It appears that more than one-half of women with FMH of 30 mL or more would not be identified if protocols were adopted to test only women in pregnancies considered to be at high risk.
E S Sebring; H F Polesky
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Transfusion     Volume:  30     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-57     Citation Subset:  IM    
Memorial Blood Center of Minneapolis, Minnesota.
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MeSH Terms
Fetomaternal Transfusion / epidemiology*
Risk Factors
Time Factors
Comment In:
Transfusion. 1991 Feb;31(2):188   [PMID:  1996487 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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