Document Detail

Feto-maternal safety of intracervical sodium nitroprusside application in sheep.
MedLine Citation:
PMID:  18836132     Owner:  NLM     Status:  MEDLINE    
The feto-maternal safety of sodium nitroprusside (SNP) administration in the cervix of pregnant sheep is evaluated. Chronically catheterized pregnant sheep at approximately 0.9 gestation were divided into 2 groups that received 0.1 mg/kg maternal body weight of SNP gel (2%) or placebo into the internal cervical os. SNP or placebo gel was administered at 9 AM with both maternal and fetal blood gas/pH, and cardiovascular parameters were monitored for 6 hours. Except for a slight transient decrease of maternal oxygen and meta-hemoglobin content, and fetal oxygen content in the SNP group, no other significant changes were observed. However, such changes are minimal and unlikely to be of any clinical significance. Moreover, nitric oxide metabolites were unchanged in both maternal and fetal circulations.These data demonstrate few, if any, effects of intrauterine SNP administration on both cellular oxygenation and cardiovascular indexes. Thus, SNP treatment, once applied into the cervix, could be considered a safe procedure.
Immacolata Blasi; Bryan Richardson; Annibale Volpe; Fabio Facchinetti
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  15     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  690-5     Citation Subset:  IM    
Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Cervix Uteri / drug effects*,  physiology*
Fetal Monitoring / methods
Heart Rate / drug effects,  physiology
Maternal-Fetal Exchange / drug effects*,  physiology
Nitroprusside / administration & dosage*,  adverse effects
Pregnancy, Animal / drug effects*,  physiology
Sheep, Domestic
Reg. No./Substance:

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