| Feto-maternal safety of intracervical sodium nitroprusside application in sheep. | |
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MedLine Citation:
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PMID: 18836132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The feto-maternal safety of sodium nitroprusside (SNP) administration in the cervix of pregnant sheep is evaluated. Chronically catheterized pregnant sheep at approximately 0.9 gestation were divided into 2 groups that received 0.1 mg/kg maternal body weight of SNP gel (2%) or placebo into the internal cervical os. SNP or placebo gel was administered at 9 AM with both maternal and fetal blood gas/pH, and cardiovascular parameters were monitored for 6 hours. Except for a slight transient decrease of maternal oxygen and meta-hemoglobin content, and fetal oxygen content in the SNP group, no other significant changes were observed. However, such changes are minimal and unlikely to be of any clinical significance. Moreover, nitric oxide metabolites were unchanged in both maternal and fetal circulations.These data demonstrate few, if any, effects of intrauterine SNP administration on both cellular oxygenation and cardiovascular indexes. Thus, SNP treatment, once applied into the cervix, could be considered a safe procedure. |
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Authors:
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Immacolata Blasi; Bryan Richardson; Annibale Volpe; Fabio Facchinetti |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 15 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-06 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 690-5 Citation Subset: IM |
Affiliation:
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Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects, physiology Cervix Uteri / drug effects*, physiology* Female Fetal Monitoring / methods Heart Rate / drug effects, physiology Maternal-Fetal Exchange / drug effects*, physiology Nitroprusside / administration & dosage*, adverse effects Pregnancy Pregnancy, Animal / drug effects*, physiology Sheep, Domestic |
| Chemical | |
Reg. No./Substance:
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15078-28-1/Nitroprusside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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