| Feto-maternal concentrations of diazepam and W-demethyldiazepam after intra-amniotic diazepam injection. | |
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MedLine Citation:
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PMID: 13006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten milligrams of diazepam were injected intraamniotically in 8 mothers prior to therapeutic abortion between 12 and 19 weeks. The diazepam concentrations in the maternal plasma were comparable to those found after the same intramuscular diazepam dose to the mother. The concentration of diazepam in the amniotic fluid 12 to 18 hours after the injection was no longer significantly higher than in the maternal plasma. The concentrations of diazepam in the fetal plasma, liver and brain were comparable to the concentrations resulting from a 10 mg intramuscular diazepam dose to the mother about 2 hours before legal abortion. The feto-maternal ratio of diazepam was of same magnitude as after the intramuscular application to the mother. The results indicate that the disappearance of diazepam from the amniotic fluid in this stage of pregnancy occurs extraplacentally, through the mambranes into the uterine circulation. In the treatment of a fetus with drugs having properties similar to diazepam, intra-amniotic administration is no better than intramuscular administration to the mother. |
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Authors:
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R Erkkola; J Kanto; L Kangas; O Piiroinen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 14 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 1976 |
Date Detail:
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Created Date: 1977-03-31 Completed Date: 1977-03-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 213-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amniotic Fluid / analysis Brain Chemistry Diazepam / administration & dosage, analogs & derivatives*, analysis*, blood Female Fetal Blood / analysis Humans Injections Injections, Intramuscular Kinetics Liver / analysis Maternal-Fetal Exchange* Nordazepam / analysis* Oxazepam / analysis Pregnancy |
| Chemical | |
Reg. No./Substance:
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1088-11-5/Nordazepam; 439-14-5/Diazepam; 604-75-1/Oxazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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