| Fetal wound healing: an in vitro explant model. | |
| | |
MedLine Citation:
|
PMID: 2401945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The ability of fetal skin wounds to heal without scar formation is remarkable. The mechanisms that endow the fetus with this unique healing ability remain unknown. We have developed an in vitro explant model using fetal sheep skin to investigate fetal wound healing. This model eliminates the complex systemic mechanisms that modulate in vivo wound healing. We demonstrated that using an enriched medium, midgestation fetal sheep skin explants following wounding reepithelialized within 4 days. By 7 days after wounding the confluent epidermis was thicker, but the dermal wound remained open. This model demonstrates that it is possible to achieve conditions in culture that maintain tissue viability and support reepithelialization. This model may allow us to resolve some of the individual components that participate in the process of scarless fetal skin healing. |
| | |
Authors:
|
D A Burd; M T Longaker; N S Adzick; C C Compton; M R Harrison; J W Siebert; H P Ehrlich |
Related Documents
:
|
17339915 - The effects of radial shock waves on the metabolism of equine cartilage explants in vitro. 16411155 - Guidelines for pubic hair restoration. 9021565 - Hyaluronic acid of wound fluid in adult and fetal rabbits. 6464655 - The role of cartilage canals in the ossification of the talus. 18032705 - Enucleation of primitive erythroid cells generates a transient population of "pyrenocyt... 16470735 - Postmortem evaluation of 220 prenatally diagnosed fetuses with neural tube defects: det... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pediatric surgery Volume: 25 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1990 Aug |
Date Detail:
|
Created Date: 1990-10-19 Completed Date: 1990-10-19 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 898-901 Citation Subset: IM |
Affiliation:
|
Harvard Medical School, Boston, MA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cells, Cultured Cicatrix / physiopathology* Culture Media Fetus Sheep Skin / physiopathology* Wound Healing / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Culture Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective use of splenectomy after liver transplantation in children.
Next Document: The blind loop syndrome in children.