Document Detail


Fetal wound healing: an in vitro explant model.
MedLine Citation:
PMID:  2401945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of fetal skin wounds to heal without scar formation is remarkable. The mechanisms that endow the fetus with this unique healing ability remain unknown. We have developed an in vitro explant model using fetal sheep skin to investigate fetal wound healing. This model eliminates the complex systemic mechanisms that modulate in vivo wound healing. We demonstrated that using an enriched medium, midgestation fetal sheep skin explants following wounding reepithelialized within 4 days. By 7 days after wounding the confluent epidermis was thicker, but the dermal wound remained open. This model demonstrates that it is possible to achieve conditions in culture that maintain tissue viability and support reepithelialization. This model may allow us to resolve some of the individual components that participate in the process of scarless fetal skin healing.
Authors:
D A Burd; M T Longaker; N S Adzick; C C Compton; M R Harrison; J W Siebert; H P Ehrlich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  25     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-19     Completed Date:  1990-10-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  898-901     Citation Subset:  IM    
Affiliation:
Harvard Medical School, Boston, MA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Cicatrix / physiopathology*
Culture Media
Fetus
Sheep
Skin / physiopathology*
Wound Healing / physiology*
Chemical
Reg. No./Substance:
0/Culture Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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