Document Detail

Fetal ventricular mass determination on three-dimensional echocardiography: studies in normal fetuses and validation experiments.
MedLine Citation:
PMID:  15326076     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Estimation of ventricular volume and mass is important for baseline and serial evaluation of fetuses with normal or abnormal hearts. Direct measurement of chamber wall volumes and mass can be made without geometric assumptions by 3D fetal echocardiography. Our goals were to determine the feasibility of using fast nongated 3D echocardiography for fetal volumetric and mass assessments, to validate the accuracy of the ultrasound system and the measurement technique, and if satisfactory, to develop normal values for fetal ventricular mass during the second and third trimesters. METHODS AND RESULTS: This was a prospective outpatient study of 90 consecutive normal pregnancies during routine obstetric services at Oregon Health & Science University (Portland). Optimized 3D volumes of the fetal thorax and cardiac chambers were rapidly acquired and later analyzed for right and left ventricular mass by radial summation technique from manual epicardial and endocardial traces. Experiments to validate the ultrasound system and measurement technique were performed with modified small balloon models and in vivo and ex vivo small animal experiments. Our study established the feasibility of fetal ventricular mass measurements with 3D ultrasound technology and developed normal values for right and left ventricular mass from 15 weeks' gestation to term. CONCLUSIONS: Nongated fast 3D fetal echocardiography is an acceptable modality for determination of cardiac chamber wall volume and mass with good accuracy and acceptable interobserver variability. The method should be especially valuable as an objective serial measurement in clinical fetal studies with structurally or functionally abnormal hearts.
Aarti Hejmadi Bhat; Virginia Corbett; Nathan Carpenter; Nick Liu; Ruolan Liu; Anna Wu; Graham Hopkins; Roya Sohaey; Carey Winkler; Christine S Sahn; Valerie Sovinsky; Xiaokui Li; David J Sahn
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Publication Detail:
Type:  Comparative Study; Journal Article; Validation Studies     Date:  2004-08-23
Journal Detail:
Title:  Circulation     Volume:  110     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-01     Completed Date:  2005-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1054-60     Citation Subset:  AIM; IM    
Clinical Care Center for Congenital Heart Disease, Oregon Health & Science University, Portland 97239-3098, USA.
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MeSH Terms
Feasibility Studies
Fetal Heart / anatomy & histology*,  growth & development,  ultrasonography
Gestational Age
Heart Ventricles / embryology*,  ultrasonography
Imaging, Three-Dimensional*
Observer Variation
Organ Size
Phantoms, Imaging
Prospective Studies
Reference Values
Reproducibility of Results
Ultrasonography, Prenatal / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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