| Fetal umbilical cord blood erythropoietin, interleukin-6, pH, pO(2), pCO(2), and base excess levels in histologic and/or clinical chorioamnionitis: is the response only inflammatory? | |
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MedLine Citation:
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PMID: 19842878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the correlation of histological chorioamnionitis (CA) with and without clinical CA with umbilical cord blood gases, erythropoietin (EPO), and interleukin-6 (IL-6) levels. METHODS: Umbilical artery blood gas analysis (pH, pO(2), pCO(2), BE) and umbilical vein EPO and IL-6 levels were measured in 202 infants from normal, histological, and no clinical CA and histological plus clinical CA pregnancies. RESULTS: Umbilical artery blood gas analyses were not different between normal controls and histological and clinical CA groups. Blanc Stage 1 histological CA had no abnormal EPO or IL-6 umbilical blood results. EPO in umbilical venous blood was elevated only in those infants with both histological and clinical CA. Umbilical vein IL-6 levels were elevated in all advanced microscopic and clinical CA. High and low EPO groups also have corresponding high and low IL-6 levels suggesting a common stimulus for these substances. CONCLUSIONS: Blanc stage I histological CA is probably clinically insignificant. CA is infrequently associated with abnormal umbilical artery blood gas levels. Advanced histological and clinical CA can elevate both EPO and IL-6 in umbilical blood and these may be key elements of mechanisms that effect fetal brain function. |
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Authors:
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William N Spellacy; Joan M McCarthy; John C M Tsibris; Enid Gilbert-Barness; Katheryne L Downes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fetal and pediatric pathology Volume: 28 ISSN: 1551-3823 ISO Abbreviation: Fetal Pediatr Pathol Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-21 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230972 Medline TA: Fetal Pediatr Pathol Country: England |
Other Details:
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Languages: eng Pagination: 239-46 Citation Subset: IM |
Affiliation:
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The Department of Obstetrics and Gynecology and the Office of Clinical Research, University of South Florida College of Medicine, Tampa, Florida 33606, USA. wrodrigu@health.usf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Gas Analysis Carbon Dioxide / blood* Case-Control Studies Chorioamnionitis / blood* Cohort Studies Erythropoietin / blood* Female Fetal Blood / chemistry* Humans Hydrogen-Ion Concentration Inflammation* Interleukin-6 / blood* Oxygen / blood* Pregnancy Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 11096-26-7/Erythropoietin; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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