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Fetal umbilical artery Doppler in small preterms: (IQ) Neurocognitive outcome at five years of age.
MedLine Citation:
PMID:  23331087     Owner:  NLM     Status:  Publisher    
AIM: To investigate if absent or reversed end-diastolic flow in the umbilical artery (AREDF) is associated with neonatal mortality, morbidity or long-term neurocognitive outcome in extremely preterm infants exposed to preeclampsia or intrauterine growth restriction. METHODS: Prenatal Doppler data were retrospectively collected for liveborn infants with gestational age (GA) <28 weeks or birth weight (BW) <1000 g, born small for gestational age (SGA- BW <5(th) percentile for GA) or of mothers with preeclampsia at the four largest university hospitals in Norway during 1999-2000. Neonatal mortality and morbidities, cerebral palsy (CP) and IQ at 5 years of age were compared for infants with or without AREDF. RESULTS: Of 260 infants, 84 were eligible and 71 of them had sufficient Doppler data. Of these, 38 (54%) had AREDF. Of 33 infants born <28 weeks, 7/19 (37%) with AREDF and none of 14 without AREDF had severe cerebral haemorrhage (SCH) (p=0.01). AREDF was not significantly associated with mortality, other NICU morbidities, CP or reduced IQ. For the 38 infants with GA ≥28 weeks AREDF (19/38) was not associated with adverse outcomes. CONCLUSION: AREDF was associated with increased risk of SCH in extremely preterm infants (GA <28 weeks). ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Siw Helen W Eger; Kristian Sommerfelt; Torvid Kiserud; Trond Markestad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Department of Clinical Medicine, University of Bergen, Norway; Department of Pediatrics, Haukeland University Hospital, Norway.
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