| Fetal trisomy 21 and the risk of preeclampsia. | |
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MedLine Citation:
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PMID: 19606400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Microchimerism has been investigated as a possible contributor to the pathophysiology of preeclampsia. Although trisomy 21 is associated with pronounced microchimerism, it has not been connected with an increased risk of preeclampsia. Our objective was to readdress the relationship between preeclampsia and trisomy 21 in a large population. METHODS: Using the Texas Birth Defects Registry for 1999-2003, a cohort of 2995 pregnancies with a trisomy 21 fetus was identified and compared with a control cohort of 1959 pregnancies with fetal isolated oral clefts. Chi-square test was used to estimate the significance of observed difference in the proportion of preeclampsia between groups. The interactive and confounding effects of covariates were examined by stratified analysis and the Mantel-Haenszel method. RESULTS: We observed 84 cases of preeclampsia in the trisomy 21 cohort (3.7%) and 111 cases in the oral cleft cohort (5.7%). The crude OR for having preeclampsia in relation to trisomy 21 was 0.63 (95% CI 0.47-0.85). The OR estimates remained the same after adjustment for confounders. CONCLUSION: Pregnancies carrying a trisomy 21 fetus do not have an increased risk of preeclampsia. Besides epidemiologic significance, our data also have relevance for genetic counseling. |
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Authors:
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Jennifer Defant; Michael J Gambello; Manju Monga; Peter H Langlois; Sarah J Noblin; Alex C Vidaeff |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-22 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 55-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School, Houston, Texas 77030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chimerism Cleft Lip / complications Cleft Palate / complications Down Syndrome / complications*, genetics Female Gestational Age Humans Maternal Age Odds Ratio Parity Pre-Eclampsia / epidemiology*, genetics Pregnancy Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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U50/CCU613232//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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