Document Detail


Fetal transfusion of red blood cells for alloimmunization: validity of a published equation.
MedLine Citation:
PMID:  19786783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To validate the equation published in 1990 by Leduc et al. for red blood cell fetal transfusion where fetoplacental blood volume (VO) = 100 ml/kg, then improve its precision. METHODS: We reviewed 101 fetal transfusions among 32 patients. We analyzed risk factors for an inaccurate estimation with uni- and multivariate analysis. We compared the obtained Leduc formula with three other published equations. RESULTS: Fetal weight and gestational age were risk factors for an inaccurate estimation of the final Hct. Before 32 weeks the estimation of VO was 120 ml/kg instead of 100 ml/kg. All formulae overestimated the mean expected Hct value. However, expected Hct estimated by Leduc's formula is the nearest of the observed final Hct. CONCLUSION: Leduc's equation seems to be accurate, but less so for the youngest fetuses. We propose an adapted formula VO according to gestational age and fetal weight estimation.
Authors:
Camille Le Ray; Lynda Hudon; Line Leduc
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Publication Detail:
Type:  Comparative Study; Journal Article; Validation Studies     Date:  2009-09-30
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  25     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-29     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
Copyright Information:
2009 S. Karger AG, Basel
Affiliation:
Department of Obstetrics and Gynecology, Sainte-Justine Hospital, Montreal, Que., Canada. camille.leray@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Blood Transfusion, Intrauterine / adverse effects,  methods*
Blood Volume
Erythrocyte Transfusion* / adverse effects
Female
Fetal Blood
Fetal Weight
Gestational Age
Hematocrit
Humans
Logistic Models
Models, Biological*
Odds Ratio
Pregnancy
Pregnancy Outcome
Reproducibility of Results
Retrospective Studies
Rh Isoimmunization / therapy*,  ultrasonography
Risk Assessment
Risk Factors
Treatment Outcome
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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