| Fetal transfusion of red blood cells for alloimmunization: validity of a published equation. | |
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MedLine Citation:
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PMID: 19786783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To validate the equation published in 1990 by Leduc et al. for red blood cell fetal transfusion where fetoplacental blood volume (VO) = 100 ml/kg, then improve its precision. METHODS: We reviewed 101 fetal transfusions among 32 patients. We analyzed risk factors for an inaccurate estimation with uni- and multivariate analysis. We compared the obtained Leduc formula with three other published equations. RESULTS: Fetal weight and gestational age were risk factors for an inaccurate estimation of the final Hct. Before 32 weeks the estimation of VO was 120 ml/kg instead of 100 ml/kg. All formulae overestimated the mean expected Hct value. However, expected Hct estimated by Leduc's formula is the nearest of the observed final Hct. CONCLUSION: Leduc's equation seems to be accurate, but less so for the youngest fetuses. We propose an adapted formula VO according to gestational age and fetal weight estimation. |
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Authors:
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Camille Le Ray; Lynda Hudon; Line Leduc |
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Publication Detail:
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Type: Comparative Study; Journal Article; Validation Studies Date: 2009-09-30 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 25 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 379-84 Citation Subset: IM |
Copyright Information:
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2009 S. Karger AG, Basel |
Affiliation:
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Department of Obstetrics and Gynecology, Sainte-Justine Hospital, Montreal, Que., Canada. camille.leray@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Transfusion, Intrauterine
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adverse effects,
methods* Blood Volume Erythrocyte Transfusion* / adverse effects Female Fetal Blood Fetal Weight Gestational Age Hematocrit Humans Logistic Models Models, Biological* Odds Ratio Pregnancy Pregnancy Outcome Reproducibility of Results Retrospective Studies Rh Isoimmunization / therapy*, ultrasonography Risk Assessment Risk Factors Treatment Outcome Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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