| Fetal tissue grafts for cerebellar atrophy. | |
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MedLine Citation:
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PMID: 2065529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been shown in a rat model that surgical injury to the right cerebellum with resultant ataxia can be corrected by implantation of embryonic cerebellar tissue into the injured cerebellum. Histological examinations of the cerebellar tissue revealed that mitoses of Purkinje cells of the implanted group were increased substantially over the control group's. The surgically induced ataxia resolved more rapidly in the cerebellar implant group than the control group. Based on this experimental data, a similar technique was applied in 6 patients with severe hereditary cerebellar degenerative ataxia. The preliminary results in these 6 surgically implanted patients with heredity degenerative cerebellar disease show 2 with marked improvement, 3 with moderate improvement and 1 with improvement for 2 months followed by mild deterioration but still better than presurgery. We also studied immunological markers in the blood and CSF in an attempt to determine whether rejection of implanted tissue occurs. |
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Authors:
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C Y Wu; X F Bao; C Zhang; Q L Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 104 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-08-12 Completed Date: 1991-08-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: CHINA |
Other Details:
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Languages: eng Pagination: 198-203 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Shandong Medical University Affiliated Hospital, Jinan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrophy Brain Tissue Transplantation* Cerebellar Ataxia / surgery* Cerebellum / embryology, pathology*, transplantation Child Female Fetal Tissue Transplantation* Humans Male Middle Aged Spinocerebellar Degenerations / surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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