Document Detail

Fetal thymic involution: a sonographic marker of the fetal inflammatory response syndrome.
MedLine Citation:
PMID:  16389025     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate whether there is a relationship between the sonographic fetal thymus size and the presence of an intrauterine infection in patients with preterm labor. STUDY DESIGN: Thirty-one women who had been admitted with preterm labor and intact membranes between 24 and 32 weeks of gestation were included. Fetal thymus perimeter was measured sonographically, and amniocentesis for the microbiologic assessment of the amniotic cavity was performed. Placentas and umbilical cords were examined for the presence of chorioamnionitis/funisitis. RESULTS: The prevalence of preterm delivery and intra-amniotic infection was 51.6% (16/31 women) and 32.3% (10/31 women), respectively. In all cases with intrauterine infection and in 23.8% of cases without intrauterine infection, the fetal thymus perimeter was below the 5th percentile for gestational age (10/10 women vs 5/21 women; P < .01). Isolated histologic chorioamnionitis and funisitis were found in 22.6% and 25.8% of fetuses, respectively. The fetal thymus was below the 5th percentile for gestational age in 100%, 71.4%, and 12.5% of patients with histologic signs of funisitis and isolated chorioamnionitis and without histologic signs of infection, respectively. CONCLUSION: Fetal thymus involution in preterm labor patients is strongly associated with funisitis, which is the histologic manifestation of the fetal inflammatory response syndrome.
Edoardo Di Naro; Antonella Cromi; Fabio Ghezzi; Luigi Raio; Stefano Uccella; Vincenzo D'Addario; Giuseppe Loverro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  194     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-03     Completed Date:  2006-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  AIM; IM    
Department of Obstetrics, University of Bari, Bari, Italy.
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MeSH Terms
Bacterial Infections*
Chorioamnionitis / microbiology*,  pathology
Gestational Age
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  mortality,  physiopathology
Obstetric Labor, Premature*
Premature Birth
Severity of Illness Index
Thymus Gland / ultrasonography*
Ultrasonography, Prenatal*

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