Document Detail


Fetal thymic involution: a sonographic marker of the fetal inflammatory response syndrome.
MedLine Citation:
PMID:  16389025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to evaluate whether there is a relationship between the sonographic fetal thymus size and the presence of an intrauterine infection in patients with preterm labor. STUDY DESIGN: Thirty-one women who had been admitted with preterm labor and intact membranes between 24 and 32 weeks of gestation were included. Fetal thymus perimeter was measured sonographically, and amniocentesis for the microbiologic assessment of the amniotic cavity was performed. Placentas and umbilical cords were examined for the presence of chorioamnionitis/funisitis. RESULTS: The prevalence of preterm delivery and intra-amniotic infection was 51.6% (16/31 women) and 32.3% (10/31 women), respectively. In all cases with intrauterine infection and in 23.8% of cases without intrauterine infection, the fetal thymus perimeter was below the 5th percentile for gestational age (10/10 women vs 5/21 women; P < .01). Isolated histologic chorioamnionitis and funisitis were found in 22.6% and 25.8% of fetuses, respectively. The fetal thymus was below the 5th percentile for gestational age in 100%, 71.4%, and 12.5% of patients with histologic signs of funisitis and isolated chorioamnionitis and without histologic signs of infection, respectively. CONCLUSION: Fetal thymus involution in preterm labor patients is strongly associated with funisitis, which is the histologic manifestation of the fetal inflammatory response syndrome.
Authors:
Edoardo Di Naro; Antonella Cromi; Fabio Ghezzi; Luigi Raio; Stefano Uccella; Vincenzo D'Addario; Giuseppe Loverro
Related Documents :
8621995 - Determinants of preterm delivery in low-risk pregnancies. the radius study group.
11964935 - Is vaginal douching associated with preterm delivery?
1340045 - Maternal nativity status and pregnancy outcome among u.s.-born filipinos.
1635725 - Unfavorable outcome in penultimate pregnancy and premature rupture of membranes in succ...
12424425 - Immunoadsorption and plasma exchange in pregnancy.
946725 - Blood circulating changes in the eye and limbs with relation to pregnancy and female se...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  194     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-03     Completed Date:  2006-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics, University of Bari, Bari, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bacterial Infections*
Chorioamnionitis / microbiology*,  pathology
Female
Gestational Age
Humans
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  mortality,  physiopathology
Obstetric Labor, Premature*
Pregnancy
Premature Birth
Severity of Illness Index
Thymus Gland / ultrasonography*
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Temporal trends in the rates of trial of labor in low-risk pregnancies and their impact on the rates...
Next Document:  Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia ...