| Fetal thrombotic vasculopathy in twin placentas with complete hydatidiform mole. | |
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MedLine Citation:
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PMID: 18702565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complete hydatidiform mole with a coexistent normal twin is rare, but the mortality rate for the coexistent twin is high, usually attributed to preeclampsia or vaginal bleeding. Placental examination of 3 twin pregnancies complicated by complete hydatidiform mole revealed significant abnormalities in the fetal vasculature. In 1 case, an intrauterine demise at 27 weeks, the placenta showed chorionic plate vessels with mural fibrin thrombi. The placenta from a second case, delivered at 30 weeks for preterm labor, showed similar thrombi in chorionic plate vessels, accompanied by calcification. A third case delivered at 35 weeks produced a liveborn infant, and the placenta showed villous stromal-vascular karyorrhexis, avascular villi, and stem villous thrombosis. Fetal placental thrombotic lesions seen in the coexistent twin circulation, associated with a complete hydatidiform mole, may play a heretofore unrecognized role in the morbidity and mortality of the fetus. |
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Authors:
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Linda M Ernst; Doris Chou; Samuel Parry |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 12 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 63-7 Citation Subset: IM |
Affiliation:
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The Children's Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, PA, USA. ernst@mail.chop.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Vessels
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pathology Female Fetus Humans Hydatidiform Mole / pathology* Placenta / blood supply*, pathology Placenta Diseases / pathology* Pregnancy Thrombosis / pathology* Twins |
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