| Fetal thickened nuchal soft tissues may first appear in the second trimester in Down syndrome. | |
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MedLine Citation:
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PMID: 19830827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe a series of cases of late-onset fetal nuchal translucency in Down syndrome. METHOD: In our practice area, most pregnant women usually undergo 3 different sonographic examinations: a fetal nuchal translucency examination in the 1st trimester and 2 detailed surveys of all fetal organs in the early 2nd trimester and in midpregnancy. RESULT: During the study period (2003-2008), we detected 11 fetuses with new appearance of severe thickened nuchal soft tissues (>or=6 mm) at 14-16 weeks' gestation after a normal nuchal screening in the 1st trimester. All of these fetuses had trisomy 21. Associated structural anomalies were observed in 10/11 of the cases. In addition, there were 12 fetuses with new appearance of thickened nuchal soft tissues (<4 mm); all these fetuses had a normal karyotype and were normal at delivery. CONCLUSION: Obstetricians should be aware that a nuchal abnormality may first appear only at 14-16 weeks' gestation. Fetal karyotyping is advocated in these cases because of the high probability of Down syndrome. |
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Authors:
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Etan Z Zimmer; Shraga Blazer; Shai Linn; Moshe Bronshtein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical ultrasound : JCU Volume: 38 ISSN: 1097-0096 ISO Abbreviation: J Clin Ultrasound Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-13 Completed Date: 2010-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401663 Medline TA: J Clin Ultrasound Country: United States |
Other Details:
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Languages: eng Pagination: 71-4 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley Periodicals, Inc. |
Affiliation:
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Department of Obstetrics and Gynecology, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, 1 Efron St., Haifa 31096, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diagnosis, Differential Down Syndrome / embryology, ultrasonography* Endosonography / methods Female Follow-Up Studies Gestational Age Humans Neck / embryology, ultrasonography* Nuchal Translucency Measurement / methods* Pregnancy Pregnancy Trimester, Second* Reproducibility of Results |
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