Document Detail

Fetal surgery for myelomeningocele: trials and tribulations. Isabella Forshall Lecture.
MedLine Citation:
PMID:  22325376     Owner:  NLM     Status:  MEDLINE    
The rationale for in utero repair of myelomeningocele (MMC) in the context of pathologic observations, animal models, and outcomes from the initial experience with human fetal MMC repair is presented. This has now culminated in a randomized trial, Management of Myelomeningocele Study, the findings of which are listed. The story is focused on the milestone contributions of members of the Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia on the road to successful fetal surgery for spina bifida. This is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying a fetus with MMC.
N Scott Adzick
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Publication Detail:
Type:  Lectures; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  47     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa 19104, USA.
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MeSH Terms
Cesarean Section
Double-Blind Method
Encephalocele / embryology
Fetal Therapies / methods*,  mortality
Fetoscopy / methods
Gestational Age
Hospitals, Pediatric
Hysterotomy / methods
Infant, Newborn
Meningomyelocele / embryology,  physiopathology,  surgery*
Multicenter Studies as Topic
Obstetric Labor, Premature / etiology
Postoperative Complications / etiology
Randomized Controlled Trials as Topic
Rhombencephalon / embryology,  pathology
Sheep / embryology
Spinal Dysraphism / embryology,  surgery
Treatment Outcome
Ventriculoperitoneal Shunt
Grant Support
U10 HD041666-01A1/HD/NICHD NIH HHS; U10 HD041666-01A1S1/HD/NICHD NIH HHS; U10 HD041666-02/HD/NICHD NIH HHS; U10 HD041666-03/HD/NICHD NIH HHS; U10 HD041666-03S1/HD/NICHD NIH HHS; U10 HD041666-03S2/HD/NICHD NIH HHS; U10 HD041666-03S3/HD/NICHD NIH HHS; U10 HD041666-04/HD/NICHD NIH HHS; U10 HD041666-05/HD/NICHD NIH HHS; U10 HD041666-05S1/HD/NICHD NIH HHS; U10 HD041666-05S2/HD/NICHD NIH HHS; U10 HD041666-05S3/HD/NICHD NIH HHS; U10 HD041666-05S4/HD/NICHD NIH HHS

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