| Fetal surgery for myelomeningocele: trials and tribulations. Isabella Forshall Lecture. | |
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MedLine Citation:
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PMID: 22325376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rationale for in utero repair of myelomeningocele (MMC) in the context of pathologic observations, animal models, and outcomes from the initial experience with human fetal MMC repair is presented. This has now culminated in a randomized trial, Management of Myelomeningocele Study, the findings of which are listed. The story is focused on the milestone contributions of members of the Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia on the road to successful fetal surgery for spina bifida. This is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying a fetus with MMC. |
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Authors:
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N Scott Adzick |
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Publication Detail:
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Type: Lectures; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 47 ISSN: 1531-5037 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-13 Completed Date: 2012-06-28 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 273-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pa 19104, USA. adzick@email.chop.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cesarean Section Double-Blind Method Encephalocele / embryology Female Fetal Therapies / methods*, mortality Fetoscopy / methods Gestational Age Hospitals, Pediatric Humans Hysterotomy / methods Infant, Newborn Meningomyelocele / embryology, physiopathology, surgery* Multicenter Studies as Topic Obstetric Labor, Premature / etiology Philadelphia Postoperative Complications / etiology Pregnancy Randomized Controlled Trials as Topic Rhombencephalon / embryology, pathology Sheep / embryology Spinal Dysraphism / embryology, surgery Treatment Outcome Ventriculoperitoneal Shunt |
| Grant Support | |
ID/Acronym/Agency:
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U10 HD041666-01A1/HD/NICHD NIH HHS; U10 HD041666-01A1S1/HD/NICHD NIH HHS; U10 HD041666-02/HD/NICHD NIH HHS; U10 HD041666-03/HD/NICHD NIH HHS; U10 HD041666-03S1/HD/NICHD NIH HHS; U10 HD041666-03S2/HD/NICHD NIH HHS; U10 HD041666-03S3/HD/NICHD NIH HHS; U10 HD041666-04/HD/NICHD NIH HHS; U10 HD041666-05/HD/NICHD NIH HHS; U10 HD041666-05S1/HD/NICHD NIH HHS; U10 HD041666-05S2/HD/NICHD NIH HHS; U10 HD041666-05S3/HD/NICHD NIH HHS; U10 HD041666-05S4/HD/NICHD NIH HHS |
| Comments/Corrections | |
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