Document Detail

Fetal surfactant as a source of arachidonate in human amniotic fluid.
MedLine Citation:
PMID:  10680776     Owner:  NLM     Status:  MEDLINE    
The factors responsible for the onset of labor in women are not well understood but it is clear that parturition is associated with increased production of prostanoids and release of arachidonic acid by intrauterine tissues. Pulmonary surfactant is secreted from the fetal lung into the amniotic fluid where its concentration increases toward term. In this paper we have shown that the ability of fetal surfactant to stimulate prostaglandin production by amnion cells is greatly enhanced by pre-incubating surfactant with amniotic fluid. This is due to the release of fatty acids, including arachidonate, from the lipids of fetal surfactant by the sequential action of phospholipase C and diglyceride lipase. Thus, in addition to providing the amnion with a source of arachidonate derived from the intracellular transfer of arachidonate from surfactant phosphatidylcholine to phosphatidylethanolamine and phosphatidylinositol in amnion cells, fetal surfactant also contributes to the pool of free arachidonate in amniotic fluid.
A L Bernal; P J Phizackerley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  60     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-01     Completed Date:  2000-03-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-70     Citation Subset:  IM    
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Women's Centre, Headington, UK.
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MeSH Terms
Amniotic Fluid / cytology,  enzymology,  metabolism*
Arachidonic Acid / metabolism*
Carbon Radioisotopes
Fatty Acids / metabolism
Lipid Metabolism
Lipoprotein Lipase / metabolism
Phosphatidylcholines / chemistry
Prostaglandins / secretion
Pulmonary Surfactants / metabolism*
Type C Phospholipases / metabolism
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Fatty Acids; 0/Phosphatidylcholines; 0/Prostaglandins; 0/Pulmonary Surfactants; 18892-74-5/1-stearoyl-2-arachidonylphosphatidylcholine; 506-32-1/Arachidonic Acid; EC Lipase; EC 3.1.4.-/Type C Phospholipases

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