Document Detail

Fetal sex pairing and adverse perinatal outcomes in twin gestations.
MedLine Citation:
PMID:  23137847     Owner:  NLM     Status:  Publisher    
PURPOSE: To assess the association between fetal sex pairing in twin pregnancies and adverse perinatal and infant outcomes. METHODS: A retrospective cohort study of 9770 infants from 4885 twin pregnancies delivered in 2007 was conducted with a statewide hospital discharge database for Texas. Log-binomial regression models based on generalized estimating equations were used to calculate relative risks (RR) and 95% confidence intervals (95% CI) for the following dichotomous outcomes: breech presentation, hospital mortality, intrauterine growth restriction (IUGR), low birth weight, prolonged length of stay (>4 days), receipt of mechanical ventilation, and respiratory distress syndrome (RDS). RESULTS: The sample was composed of 4918 females and 4852 males. An approximately equal number of infants were from a female-female pregnancy (n = 3270), mixed-sex pregnancy (n = 3296), and a male-male pregnancy (n = 3204). Twins of either sex from mixed-sex pairs were 45% less likely to die in the hospital compared with females from a female-female pregnancy (RR, 0.55, 95% CI, 0.31-0.98). Males from a male-male pair were 33% less likely than females from female-female pairs to experience IUGR (RR, 0.67; 95% CI, 0.53-0.83). The incidence of RDS was significantly increased in males from male-male twin pairs versus females from female-female pairs (RR, 1.21; 95% CI, 1.05-1.41). CONCLUSIONS: Male infants from male-male twin pairs were more likely to develop RDS and be placed on a ventilator but less likely to experience IUGR than female infants from female-female pairs.
Zuber D Mulla; Sanja Kupesic Plavsic; Melchor Ortiz; Bahij S Nuwayhid; Cande V Ananth
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-5
Journal Detail:
Title:  Annals of epidemiology     Volume:  -     ISSN:  1873-2585     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso; University of Texas School of Public Health at Houston, El Paso Regional Campus, El Paso. Electronic address:
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