Document Detail

Fetal rhabdomyoma: prenatal diagnosis, clinical outcome, and incidence of associated tuberous sclerosis complex.
MedLine Citation:
PMID:  14615733     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We reviewed our institution's experience with fetal cardiac rhabdomyoma to document the clinical outcome and incidence of associated tuberous sclerosis complex (TSC) and compared our findings with those of patients diagnosed with cardiac rhabdomyoma after birth. STUDY DESIGN: We reviewed the medical records of all cases diagnosed prenatally and postnatally with cardiac rhabdomyoma between January 1990 and June 2002. RESULTS: Twenty fetuses with cardiac rhabdomyoma were diagnosed at 28.4+/-6.0 weeks' gestational age. Of 19 continued pregnancies, there was one spontaneous intrauterine death, and 18 were delivered at term. Although none had prenatal hemodynamic complications, after birth seven had cardiac symptoms requiring medical (n=4) or surgical intervention (n=3). On follow-up, 15 of 19 with available outcome had TSC (79%), including six with neurodevelopmental disease. Over the same period, 26 patients were diagnosed with cardiac rhabdomyoma postnatally. Most (77%) were referred for cardiac assessment after findings suggesting TSC. On follow-up, TSC was confirmed in 25 (96%), including 22 with neurodevelopmental disease. The incidence of cardiac symptoms and TSC was not statistically different between the prenatal and postnatal diagnosis groups. CONCLUSIONS: Cardiac rhabdomyomas are benign from the cardiovascular standpoint in most affected fetuses. As observed in postnatally diagnosed cardiac rhabdomyoma, TSC is diagnosed in most cases of fetal cardiac rhabdomyoma.
Rima S Bader; David Chitayat; Edmond Kelly; Greg Ryan; Jeffrey F Smallhorn; Ants Toi; Lisa K Hornberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  143     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  620-4     Citation Subset:  AIM; IM    
Department of Pediatrics, Division of Cardiology, Fetal Cardiac Program, the Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Brain / radiography
Developmental Disabilities / epidemiology
Fetal Diseases / diagnosis,  epidemiology
Follow-Up Studies
Gestational Age
Heart Neoplasms / diagnosis*,  epidemiology,  ultrasonography
Pregnancy Outcome
Prenatal Diagnosis*
Referral and Consultation
Rhabdomyoma / diagnosis*,  epidemiology,  ultrasonography
Tuberous Sclerosis / diagnosis*,  epidemiology

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