Document Detail

Fetal reversed constrictive effect of indomethacin and postnatal delayed closure of the ductus arteriosus following administration of transplacental magnesium sulfate in rats.
MedLine Citation:
PMID:  19279396     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Magnesium sulfate (MgSO4) is used therapeutically for eclampsia and tocolysis. Some reports have suggested a relationship between therapeutic MgSO4 and patent ductus arteriosus (DA) in preterm infants. OBJECTIVES: To clarify patent DA induction by MgSO4 in preterm infants, we studied the increase in serum Mg concentrations and fetal dilatation and postnatal delayed closure of the ductus, using transplacental MgSO4 in rats. METHODS: Fetal and neonatal ductus diameters were measured with a microscope and a micrometer after rapid whole-body freezing. In the postnatal study, 21-day pregnant dams were administered a subcutaneous injection of MgSO4 1-3 h before delivery, and the ductus was studied 0, 15, 30, 60 and 120 min after birth. In the fetal study, MgSO4 (1 g/kg) and indomethacin (10 mg/kg) were simultaneously administered to 21-day dams and the fetal ductus was studied 1, 2 and 4 h later. Serum Mg concentration was measured in the dams and newborns. RESULTS: Neonatal Mg concentrations increased from 3.8 to 4.7 and 5.8 mg/dl at 1 and 3 h after maternal administration of MgSO4. Following MgSO4 administration 3 h before birth, closure of the neonatal DA was delayed. The ductus diameter was 0.88 mm (0.80 mm in control) at 0 min, and 0.26 mm (0.08 mm in the control) at 60 min after birth. In the fetal study, MgSO4 initially reversed and later attenuated the ductus-constricting effect of indomethacin. CONCLUSIONS: Hypermagnesemia induced by transplacental MgSO4 attenuates the fetal ductus-constricting effects of indomethacin, and delays postnatal ductal closure in rats.
Katsuaki Toyoshima; Kazuo Momma; Toshio Nakanishi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-12
Journal Detail:
Title:  Neonatology     Volume:  96     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Section of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
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MeSH Terms
Animals, Newborn
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Disease Models, Animal
Drug Antagonism
Ductus Arteriosus / drug effects*,  pathology,  physiopathology
Ductus Arteriosus, Patent / drug therapy*,  pathology
Embryo, Mammalian / drug effects,  embryology
Indomethacin / pharmacology*
Magnesium Sulfate / pharmacokinetics,  pharmacology*
Maternal-Fetal Exchange*
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects
Rats, Wistar
Tocolytic Agents / pharmacokinetics,  pharmacology*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Tocolytic Agents; 53-86-1/Indomethacin; 7487-88-9/Magnesium Sulfate

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