Document Detail

Fetal renal maldevelopment with oligohydramnios following maternal use of piroxicam.
MedLine Citation:
PMID:  7819009     Owner:  NLM     Status:  MEDLINE    
A female neonate, born by cesarean section at 37 weeks of gestation, presented with respiratory distress syndrome, right pneumothorax and anuria. A sonogram showed increased echogenicity, with neither hydronephrosis nor macroscopic cysts. Peritoneal dialysis was started on the 14th day because of renal insufficiency, but the newborn died on the 33rd day. Family history was unremarkable, except that the mother received piroxicam at about the 26th week of gestation. A sonogram at the 28th week showed oligohydramnios. Histopathological study of the kidneys revealed crowded glomeruli and only few differentiated proximal convoluted tubules in the inner cortex, abnormally differentiated microcystic tubules and microcystic glomeruli in the outer cortex. Periodic acid-Schiff staining showed only traces of brush border in the dilated tubules of the outer cortex. Immunoperoxidase staining for epithelial membrane antigen was positive in the luminal border of all tubules. Electron microscopy confirmed the presence of brush border remnants and other proximal tubular characteristics in some segments. The renal abnormality bears some similarities to that found in familiar renal tubular dysgenesis, but it fits better with those described after maternal use of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs. The lesion in this case appears to have resulted from fetal exposure to piroxicam. Recently, a second pregnancy ended in a completely normal female newborn.
L E Voyer; R Drut; J H Méndez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  8     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-16     Completed Date:  1995-02-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  592-4     Citation Subset:  IM    
Department of Paediatrics, Deutsche Hospital, Buenos Aires, Argentina.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Infant, Newborn
Kidney / abnormalities*,  embryology*,  pathology
Kidney Failure / chemically induced,  pathology
Oligohydramnios / etiology*
Piroxicam / adverse effects*
Reg. No./Substance:

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