| Fetal renal contribution to amniotic fluid osmolality during maternal hypertonicity. | |
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MedLine Citation:
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PMID: 3946639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contribution of fetal urine to the increase in amniotic fluid osmolality during maternal hypertonicity was studied in chronically catheterized sheep of 130-135 days gestation. Nine percent NaCl was injected simultaneously into fetal and maternal veins, followed by a continuous infusion into the maternal vein. Maternal and fetal plasma osmolalities rose by 15 +/- 1 (SE) and 13 +/- 1 mosmol/kg, respectively, and remained constant for 4 h. Fetal urine osmolality rose significantly from 188 +/- 31 to 277 +/- 32 mosmol/kg within 1 h and remained constant thereafter. Fetal urine flow rose transiently, fell to normal within 10 min, and averaged 70% of normal beyond 1 h. Amniotic fluid osmolality rose by 10.8 +/- 2.8 mosmol/kg over 4 h. Following hypertonic injection into three fetuses blocked by the arginine vasopressin antagonist d(CH2)5D-tyr(Et)VAVP, urine osmolality did not change, and amniotic fluid osmolality rose by 2.7 +/- 0.3 mosmol/kg. Thus it appears that the increase in amniotic fluid osmolality during maternal hypertonicity may be due largely to an increased fetal urine osmolality coupled with a decreased flow of fetal urine into the amniotic space, rather than to bulk flow of fluid across the membranes and uterine wall. |
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Authors:
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L L Woods |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 250 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-19 Completed Date: 1986-03-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R235-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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analysis* Animals Arginine Vasopressin / antagonists & inhibitors Female Hydrogen-Ion Concentration Kidney / embryology* Maternal-Fetal Exchange* Osmolar Concentration Pregnancy Saline Solution, Hypertonic / pharmacology* Sheep Sodium Chloride / pharmacology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD-13949/HD/NICHD NIH HHS; HD-17312/HD/NICHD NIH HHS; HL-07092/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Saline Solution, Hypertonic; 113-79-1/Arginine Vasopressin; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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