| Fetal pulmonary vasodilation and vasoreactivity during metabolic acidaemia. | |
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MedLine Citation:
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PMID: 3221058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the pulmonary vascular response to progressive metabolic acidaemia and to an abrupt increase in oxygen tension during metabolic acidaemia in 8 chronically-prepared fetal sheep. Left pulmonary artery blood flow was measured by electromagnetic flow transducer. Two and a half hour infusion of NH4Cl into the fetal inferior vena cava caused pH to fall to 6.94 +/- 0.01 from 7.37 +/- 0.01 (P less than 0.001). During this period of progressive metabolic acidaemia, left pulmonary artery blood flow increased from a baseline value of 60 +/- 8 to 105 +/- 14 ml.min-1 (P less than 0.002). Pulmonary artery pressure did not change significantly and calculated pulmonary vascular resistance fell indicating fetal pulmonary vasodilation. PO2 rose significantly (19.8 +/- 0.7 to 24.1 +/- 1.8 torr; P less than 0.03) and oxygen saturation fell (54.6 +/- 2.8% to 38.9 +/- 3.5%; P less than 0.001) confirming a rightward shift of the oxyhaemoglobin dissociation curve. During acidaemia, administration of 100% oxygen to the ewe further increased fetal PO2 to 37.9 +/- 2.3 torr within 10 min (P less than 0.001) and this increase in PO2 was accompanied by an increase in left pulmonary artery blood flow (P less than 0.001), a fall in pulmonary artery pressure (P less than 0.03) and a decrease in pulmonary vascular resistance (P less than 0.001) indicating further vasodilation. The response of the fetal pulmonary circulation to a 2-h period of increased oxygen tension was qualitatively similar in acidaemic and non-acidaemic fetuses. We conclude that the progressive metabolic acidaemia imposed by these experimental conditions increases pulmonary blood flow likely through an increase in fetal PO2 and that metabolic acidaemia does not block the normal vasodilatory response to an increase in oxygen tension. |
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Authors:
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F J Accurso; R B Wilkening |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of developmental physiology Volume: 10 ISSN: 0141-9846 ISO Abbreviation: J. Dev. Physiol. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1989-03-22 Completed Date: 1989-03-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910737 Medline TA: J Dev Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 411-21 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Colorado School of Medicine, Denver. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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physiopathology* Animals Fetus / physiology* Pulmonary Artery / physiology* Pulmonary Circulation* Sheep / physiology* Vascular Resistance Vasodilation* |
| Grant Support | |
ID/Acronym/Agency:
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HD-00781/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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