Document Detail

Fetal pulmonary artery diameter measurements as a predictor of morbidity in antenatally diagnosed congenital diaphragmatic hernia: a prospective study.
MedLine Citation:
PMID:  16777047     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to examine the size and growth of fetal pulmonary artery diameters in congenital diaphragmatic hernia and assess their correlation with postnatal survival and morbidity outcomes. STUDY DESIGN: Prospective antenatal echocardiographic examination of fetal branch pulmonary arteries were correlated with postnatal survival and respiratory morbidity in cases of congenital diaphragmatic hernia. Receiver operator curves were developed to assess their utilization as predictors of respiratory morbidity and survival. RESULTS: Twenty-one cases were diagnosed antenatally over 3 years. Fifteen subjects survived postnatally. The ipsilateral fetal branch pulmonary artery diameter was smaller throughout gestation in left-sided congenital diaphragmatic hernia (P = .008). The small left pulmonary diameter did not correlate with survival but correlated strongly with morbidity outcomes. Progressive ipsilateral fetal pulmonary artery hypoplasia was demonstrated throughout gestation in subjects who died or had severe morbidity. CONCLUSION: Fetal pulmonary artery diameter measurements correlate with respiratory morbidity in postnatal congenital diaphragmatic hernia and may assist with prediction of outcome. Survival has improved, possibly because of improved postnatal management of congenital diaphragmatic hernia, limiting this measurement in assessing survival.
Jenni Sokol; Naoki Shimizu; Desmond Bohn; Dorota Doherty; Greg Ryan; Lisa K Hornberger
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Publication Detail:
Type:  Journal Article     Date:  2006-06-13
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-07     Completed Date:  2006-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-7     Citation Subset:  AIM; IM    
Department of Neonatal Paediatrics, Women's and Children's Health Service, The University of Western Australia, Perth, Western Australia.
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MeSH Terms
Fetal Heart / ultrasonography
Gestational Age
Hernia, Diaphragmatic / congenital,  pathology*
Infant, Newborn
Length of Stay
Prospective Studies
Pulmonary Artery / embryology*,  pathology*
ROC Curve
Respiration, Artificial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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