| Fetal pulmonary artery diameter measurements as a predictor of morbidity in antenatally diagnosed congenital diaphragmatic hernia: a prospective study. | |
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MedLine Citation:
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PMID: 16777047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the study was to examine the size and growth of fetal pulmonary artery diameters in congenital diaphragmatic hernia and assess their correlation with postnatal survival and morbidity outcomes. STUDY DESIGN: Prospective antenatal echocardiographic examination of fetal branch pulmonary arteries were correlated with postnatal survival and respiratory morbidity in cases of congenital diaphragmatic hernia. Receiver operator curves were developed to assess their utilization as predictors of respiratory morbidity and survival. RESULTS: Twenty-one cases were diagnosed antenatally over 3 years. Fifteen subjects survived postnatally. The ipsilateral fetal branch pulmonary artery diameter was smaller throughout gestation in left-sided congenital diaphragmatic hernia (P = .008). The small left pulmonary diameter did not correlate with survival but correlated strongly with morbidity outcomes. Progressive ipsilateral fetal pulmonary artery hypoplasia was demonstrated throughout gestation in subjects who died or had severe morbidity. CONCLUSION: Fetal pulmonary artery diameter measurements correlate with respiratory morbidity in postnatal congenital diaphragmatic hernia and may assist with prediction of outcome. Survival has improved, possibly because of improved postnatal management of congenital diaphragmatic hernia, limiting this measurement in assessing survival. |
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Authors:
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Jenni Sokol; Naoki Shimizu; Desmond Bohn; Dorota Doherty; Greg Ryan; Lisa K Hornberger |
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Publication Detail:
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Type: Journal Article Date: 2006-06-13 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 195 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-07 Completed Date: 2006-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 470-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Neonatal Paediatrics, Women's and Children's Health Service, The University of Western Australia, Perth, Western Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fetal Heart
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ultrasonography Gestational Age Hernia, Diaphragmatic / congenital, pathology* Humans Infant, Newborn Length of Stay Morbidity Prospective Studies Pulmonary Artery / embryology*, pathology* ROC Curve Respiration, Artificial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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