Document Detail


Fetal programming of hypertension.
MedLine Citation:
PMID:  16352854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous epidemiological studies suggest an inverse relationship between low birth weight (LBW) and hypertension, an observation now supported by numerous animal studies. The mechanisms linking LBW and hypertension appear to be multifactorial and involve alterations in the normal regulatory systems and renal functions involved in the long-term control of arterial pressure. Recent studies using animal models of fetal programming suggest that programming during fetal life occurs in response to an adverse fetal environment and results in permanent adaptive responses that lead to structural and physiological alterations and the subsequent development of hypertension. This review summarizes the adaptive responses observed in the different models used to induce a suboptimal fetal environment and discusses insights into the mechanisms mediating the fetal programming of hypertension.
Authors:
Barbara T Alexander
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  290     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-14     Completed Date:  2006-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1-R10     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Mississippi Medical Center, 2500 N. State St. Jackson, MS 39216-4505, USA. balexander@physiology.umsmed.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetus / physiology*,  physiopathology*
Humans
Hypertension / physiopathology*
Infant, Low Birth Weight / physiology*
Infant, Newborn
Kidney / cytology,  physiopathology
Pregnancy
Renin-Angiotensin System / physiology
Grant Support
ID/Acronym/Agency:
HL-074927/HL/NHLBI NIH HHS; HL-51971/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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