| Fetal programming: causes and consequences as revealed by studies of dietary manipulation in rats -- a review. | |
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MedLine Citation:
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PMID: 16533523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During pregnancy, the developing fetus is dependent on its mother for all nutritional requirements. It is not surprising, therefore, that variations in maternal nutrition can be reflected in alterations in fetal health and well-being. Interestingly, the changes can persist into adulthood and may result in increased risk of diseases such as diabetes, obesity and cardiovascular disease. The first observations of these phenomena resulted in the development of hypotheses collectively brought under the heading of "fetal" or, more recently, "developmental" programming. In this review, we will examine some of the animal models used to understand the mechanisms involved and attempt to determine whether there are common, "gatekeeper", pathways or genes, altered by the different nutritional stresses. We will concentrate primarily on nutrition related to post-natal development of hypertension and will restrict the review to studies in rodents, since that is where most of the mechanistic studies are being undertaken. Our conclusions are that, while there may well be some common gatekeeper pathways, there is also some diversity of mechanism which may contribute to the generation of the same or similar phenotypes. |
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Authors:
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H J McArdle; H S Andersen; H Jones; L Gambling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-03-13 |
Journal Detail:
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Title: Placenta Volume: 27 Suppl A ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-18 Completed Date: 2006-09-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: S56-60 Citation Subset: IM |
Affiliation:
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Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK. h.mcardle@rowett.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Anemia, Iron-Deficiency / diet therapy, pathology Animals Diet Diet, Fat-Restricted Diet, Protein-Restricted Female Fetal Development Fetal Growth Retardation / diet therapy, etiology Hypertension / etiology Maternal Nutritional Physiological Phenomena* Pregnancy Pregnancy, Animal / physiology* Prenatal Exposure Delayed Effects* Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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