Document Detail

Fetal progenitor cells naturally transferred through pregnancy participate in inflammation and angiogenesis during wound healing.
MedLine Citation:
PMID:  21974929     Owner:  NLM     Status:  Publisher    
The phenotype and fate of fetal microchimeric cells transfered into the maternal circulation during pregnancy are not well described. Since progenitors from distal sites mobilize during wound healing, we analyzed the recruitment and plasticity of fetal progenitors into maternal wounds. Wounds were generated on normal and bleomycin-induced fibrotic skin of parous or pregnant wild-type females with fluorescent GFP(+) fetuses. Analyses were performed on skin and blood specimens through PCR, immunohistochemistry, and flow cytometry. Controls consisted of parous and pregnant females without wounds and virgin females with wounds. Fetal cells were detected in all skin specimens of parous mice as long as healing was not achieved. During early stages of wound healing, fetal cells expressed mainly leukocyte markers, while in later phases endothelial markers prevailed. Fetally derived vessels connected to maternal circulation were also found, demonstrating the transfer of fetal endothelial progenitor cells. Wounding mobilized fetal CD34(+)ckit(- )cells into the blood during pregnancy. Most of this population was CD11b(-)VEGFR2(-). Another part was CD11b(+) with a fraction expressing VEGFR2. VEGFa-spiked Matrigel plugs partially mimicked this fetal progenitor recruitment and mobilization into the blood. In summary, fetal cells that mobilize in response to wounding are mainly progenitor cells and participate in angiogenesis and inflammation.-Nassar, D., Droitcourt, C., Mathieu-d'Argent, E., Kim, M. J., Khosrotehrani, K., Aractingi, S. Fetal progenitor cells naturally transferred through pregnancy participate in inflammation and angiogenesis during wound healing.
Dany Nassar; Catherine Droitcourt; Emmanuelle Mathieu-d'Argent; Min Ji Kim; Kiarash Khosrotehrani; Selim Aractingi
Related Documents :
15101079 - Cardiothoracic ratio in the first half of pregnancy.
11084959 - Fetal biometry at 4300 m compared to sea level in peru.
12601839 - In-utero development of the fetal colon and rectum: sonographic evaluation.
3548369 - Fetal foot length as a predictor of gestational age.
12846699 - Accuracy of ultrasound dating formulae in the late second-trimester in pregnancies conc...
19462489 - Fetal and postnatal growth and blood pressure at the age of 2 years. the generation r s...
25037919 - Prenatal screening for congenital anomalies: exploring midwives' perceptions of counsel...
6423699 - The fibrinolytic system in pre-eclampsia.
7945909 - Congenital toxoplasmosis in twins: a case report.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-5
Journal Detail:
Title:  The FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  -     ISSN:  1530-6860     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Université Pierre et Marie Curie-Paris 6, Unité Mixte de Recherche (UMR) 938, Paris France;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thyroid hormone drives fetal cardiomyocyte maturation.
Next Document:  Two strikes: limited NIH R55 and R56 retooling funds and abolishment of the A2 grant mechanism.